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["2021年度基础研究面上项目拟资助项目清单"]
["序号","项目名称","单位名称","拟资助金额（万元）"]
[1,"大规模可扩展的高安全高效能联盟链共识机制研究","北京大学深圳研究生院",{"v":60,"d":"60.00"}]
[2,"缺血性心力衰竭的多尺度心肌力学机理研究","北京大学深圳研究生院",{"v":60,"d":"60.00"}]
[3,"基于同步辐射和中子源的无钴层状正极材料的构效关系研究","北京大学深圳研究生院",{"v":60,"d":"60.00"}]
[4,"DHP2诱导肺腺癌细胞程序性死亡和顺铂化疗敏感性研究","北京大学深圳医院",{"v":30,"d":"30.00"}]
[5,"热休克蛋白调节线粒体蛋白质稳态与心脏功能的机制研究","北京大学深圳医院",{"v":30,"d":"30.00"}]
[6,"MPF调控卵母细胞第二次减数分裂纺锤体快速组装的分子机制","北京大学深圳医院",{"v":30,"d":"30.00"}]
[7,"miR-29金纳米靶向抗肾纤维化的作用及机制研究","北京大学深圳医院",{"v":30,"d":"30.00"}]
[8,"pH响应软骨双靶向纳米颗粒的构建及其携载白藜芦醇在骨关节炎治疗中的作用和机制研究","北京大学深圳医院",{"v":30,"d":"30.00"}]
[9,"TSP-1在机械力诱导的增生性瘢痕中的作用及机制探究","北京大学深圳医院",{"v":30,"d":"30.00"}]
[10,"PLGA/Lipid纳米控释微泡超声引导可视化靶向药物递送治疗AS的研究","北京大学深圳医院",{"v":30,"d":"30.00"}]
[11,"基于胆汁酸-FXR信号通路探讨肠道菌群参与妊娠期糖尿病发病机制的研究","北京大学深圳医院",{"v":25,"d":"25.00"}]
[12,"缺氧诱导因子-1α相关信号通路在高度近视性巩膜重塑中的作用","北京大学深圳医院",{"v":21,"d":"21.00"}]
[13,"组蛋白H3K36me3调节冠状血管发育的细胞与分子机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[14,"内质网钙释放通道IP3R在心肌重构过程中的作用与机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[15,"RISC复合物成分异常通过miR-145-5p/CYP2C19调控急性冠脉综合征血小板反应活性的功能机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[16,"雄激素受体调控精子发生的空间转录组学研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[17,"HPV通过调控YAP1-LATS2负反馈回路参与宫颈癌发生发展的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[18,"表观酶GCN5通过自噬调控骨质疏松中骨形成的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[19,"三点固定理论指导下骨小梁金属垫块重建复杂髋臼侧骨缺的生物力学研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[20,"PI3K/AKT信号通过c-Myc介导的巨噬细胞向M2亚型极化调控骨免疫微环境再生修复股骨头坏死的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[21,"沉默HKDC1诱导线粒体ROS介导NK/T细胞淋巴瘤焦亡及其机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[22,"尘螨Der p1抗原激活PAR2-TSLP通路诱发过敏进程2型炎症的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[23,"经组胺素1修饰的3D打印磷酸三钙支架促进干细胞粘附及介导骨再生的研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[24,"基于 FANCE/Wnt/β-catenin信号途径调控的肿瘤相关巨噬细胞M1/M2表型探讨其在口腔鳞癌细胞侵袭及转移中的作用机制","北京大学深圳医院",{"v":20,"d":"20.00"}]
[25,"BRAFV600E通过直接抑制TRIM21/Oct-1负反馈环路促进甲状腺癌发生发展的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[26,"AIF1驯化巨噬细胞诱导抑制性肿瘤免疫微环境促进卵巢癌进展的作用及分子机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[27,"青蒿烯抗肿瘤靶蛋白的筛选鉴定及其作用机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[28,"miR-205/ZEB2通路调控的循环肿瘤细胞EMT在结直肠癌肝转移中的作用","北京大学深圳医院",{"v":20,"d":"20.00"}]
[29,"UBE2T与CHEK1互作通过促进DNA损伤修复诱导非小细胞肺癌放疗抵抗的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[30,"光声动力联合MnO2/Ce6@PEG-cGRD治疗TNBC的可行性及其机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[31,"仿生金银纳米棒增敏结直肠癌肝转移放化疗的实验研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[32,"MDM2抑制剂APG115通过IRF-8通路逆转难治性甲状腺癌免疫治疗抵抗的研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[33,"聚焦超声联合AR靶向逆转GBM对替莫唑胺耐药的机制研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[34,"基于生物正交化学反应靶向促进干细胞分化用于帕金森病治疗","北京大学深圳医院",{"v":20,"d":"20.00"}]
[35,"基于骨肿瘤细胞膜包覆的仿生还原响应纳米前药的构建及其在骨肿瘤靶向、SO2递送及协同治疗中的应用","北京大学深圳医院",{"v":20,"d":"20.00"}]
[36,"临床应用级间充质干细胞外泌体的优化制备和鉴定","北京大学深圳医院",{"v":20,"d":"20.00"}]
[37,"超声协同载藤黄酸PLGA纳米微泡复合物靶向治疗脑胶质瘤的实验研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[38,"新型冠状病毒疫情下口腔诊室气溶胶的产生机制及防护策略研究","北京大学深圳医院",{"v":20,"d":"20.00"}]
[39,"UGT1A1酶活性靶向荧光识别工具的设计、构建及其在中药-西药临床合理联用中的应用","北京大学深圳医院",{"v":16,"d":"16.00"}]
[40,"Smad7对树突状细胞活化迁移的影响及其在类风湿关节炎发病中的作用","北京大学深圳医院",{"v":15,"d":"15.00"}]
[41,"肿瘤相关成纤维细胞通过CXCL14/IGF-1R/ANGPTL4促进非小细胞肺癌铂类耐药的机制研究","北京大学深圳医院",{"v":14,"d":"14.00"}]
[42,"人多能干细胞来源的胆囊上皮类器官体外模型的建立","北京中医药大学深圳医院（龙岗)",{"v":20,"d":"20.00"}]
[43,"基于Nogo-A调控TRPV1表达探讨艾灸治疗慢性内脏痛的作用机制","北京中医药大学深圳医院（龙岗)",{"v":20,"d":"20.00"}]
[44,"深圳市青少年阈下抑郁的中医证候特征及其心境诱导干预的近红外脑成像研究","北京中医药大学深圳医院（龙岗)",{"v":20,"d":"20.00"}]
[45,"基于网络药理学探索左归丸受体选择性防治LAR亚型三阴性乳腺癌的“异病同治”新机制","北京中医药大学深圳医院（龙岗)",{"v":16,"d":"16.00"}]
[46,"基于生物钟自噬介导铁死亡探讨针刺改善脑出血后神经功能损伤的机制研究","北京中医药大学深圳医院（龙岗)",{"v":15,"d":"15.00"}]
[47,"针刺通过调控NIX/BNIP3通路介导线粒体自噬对阿尔茨海默大鼠脑保护作用的机制研究","北京中医药大学深圳医院（龙岗)",{"v":15,"d":"15.00"}]
[48,"智能无人系统地下空间高精度定位理论与方法","测绘遥感信息工程国家重点实验室深圳研发中心",{"v":60,"d":"60.00"}]
[49,"基于生物合理性的脉冲神经网络训练算法研究","电子科技大学（深圳）高等研究院",{"v":60,"d":"60.00"}]
[50,"基于时空众包平台的智能任务分配理论与技术研究","电子科技大学（深圳）高等研究院",{"v":60,"d":"60.00"}]
[51,"兼容sub-6GHz的一体化毫米波射频前端协作通信方法研究","电子科技大学（深圳）高等研究院",{"v":60,"d":"60.00"}]
[52,"基于单细胞DNA甲基化数据的癌细胞亚群识别方法研究","电子科技大学（深圳）高等研究院",{"v":60,"d":"60.00"}]
[53,"基于原位反应的喷墨打印柔性电磁超材料研究","电子科技大学（深圳）高等研究院",{"v":60,"d":"60.00"}]
[54,"基于超稳定纳米孔金膜的单粒子冷冻电镜样品基底技术的研究","电子科技大学（深圳）高等研究院",{"v":58,"d":"58.00"}]
[55,"多功能胶体粒子绿色合成方法研究","电子科技大学（深圳）高等研究院",{"v":50,"d":"50.00"}]
[56,"多模态知识图谱的通用表示学习","电子科技大学（深圳）高等研究院",{"v":48,"d":"48.00"}]
[57,"融合上下文情感的人体行为智能化理解和人机交互研究","电子科技大学（深圳）高等研究院",{"v":40,"d":"40.00"}]
[58,"新型可原位交联路易斯酸空穴掺杂剂构筑高效、稳定钙钛矿太阳电池研究","电子科技大学（深圳）高等研究院",{"v":40,"d":"40.00"}]
[59,"多模卫星导航系统快速定位技术研究","电子科技大学（深圳）高等研究院",{"v":40,"d":"40.00"}]
[60,"ZFP281与BRCA2相互作用调控R-loop的机理研究","东南大学深圳研究院",{"v":60,"d":"60.00"}]
[61,"锌指蛋白ZFP148在中内胚层特化中的功能研究","东南大学深圳研究院",{"v":60,"d":"60.00"}]
[62,"通过腺相关病毒介导GPA，Espin和DKK3协同调控内耳干细胞再生听觉毛细胞的研究","东南大学深圳研究院",{"v":60,"d":"60.00"}]
[63,"基于多源数据的光伏组件异常诊断与评估","东南大学深圳研究院",{"v":60,"d":"60.00"}]
[64,"选区激光熔化成型中缺陷识别与成型质量智慧管理","东南大学深圳研究院",{"v":50,"d":"50.00"}]
[65,"面向人物交互的人体视觉行为深度理解及应用研究","东南大学深圳研究院",{"v":40,"d":"40.00"}]
[66,"微纳结构多功能创面修复支架的构建与应用研究","东南大学深圳研究院",{"v":40,"d":"40.00"}]
[67,"溶藻弧菌c-di-GMP受体筛选及调控生物被膜影响菌体定植的研究","广东海洋大学深圳研究院",{"v":60,"d":"60.00"}]
[68,"基于单细胞全长转录组测序的石斑鱼T细胞分化和可变剪接异质性特征分析","广东海洋大学深圳研究院",{"v":60,"d":"60.00"}]
[69,"粤港澳大湾区台风-风暴潮的致灾机理及其灾害预测与智能应对风险技术研究","广东海洋大学深圳研究院",{"v":60,"d":"60.00"}]
[70,"深圳湾红树林微塑料时空分布特征及其在大型底栖动物食物链中的传递规律研究","广东海洋大学深圳研究院",{"v":60,"d":"60.00"}]
[71,"光纤表面微腔制备及其在海洋状态检测中的应用研究","广东海洋大学深圳研究院",{"v":40,"d":"40.00"}]
[72,"针刺通过下调TMEM16A对背根神经节自噬的抑制减轻神经病理性疼痛的研究","广州中医药大学深圳医院（福田）",{"v":20,"d":"20.00"}]
[73,"基于LncRNAs动态调控的组蛋白甲基化修饰探讨补肾中药治疗卵巢早衰的表观遗传机制","广州中医药大学深圳医院（福田）",{"v":20,"d":"20.00"}]
[74,"基于PGC-1α/Nrf2信号通路调控线粒体功能探讨黄连素防治脓毒症心肌细胞损伤的分子机制","广州中医药大学深圳医院（福田）",{"v":20,"d":"20.00"}]
[75,"温针灸烫伤烧损创新防护用具的研制与应用研究","广州中医药大学深圳医院（福田）",{"v":6,"d":"6.00"}]
[76,"面向复杂工业环境下异构机器人的动态自适应5G关键技术","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[77,"空间探测无磁控卫星磁场精确测量关键技术研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[78,"在随机噪声和时滞影响下多种群型传染病时空传播的模型研究及其应用","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[79,"地球前兆激波瞬态活动对南方地区通信导航的影响及二维监测","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[80,"基于亚波长光栅波导微环模式分裂的生物检测芯片研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[81,"云存储医疗数据的安全审计、密文搜索与隐私计算技术研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[82,"基于金属卤化钙钛矿单晶微纳阵列的高性能micro-LEDs的制备及应用研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[83,"基于关键点检测的高维混合数据聚类方法研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[84,"无人零售环境下的多模态协同学习关键技术研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[85,"新型对称突变光纤结构锁模的可调控超快光纤激光器研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[86,"面向可见光通信DCO-OFDM系统盲信号检测理论与方法研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[87,"基于混合交通流的智慧公交车路协同控制技术研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[88,"金星空间激波前兆区磁场湍动的研究：基于金星快车观测","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[89,"面向AR/MR近眼显示的衍射光栅光波导关键技术研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[90,"表面等离子体共振增强的光热催化室内空气杀菌消毒净化涂层材料的研发与应用","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[91,"新型近红外二区荧光脂质体的制备及其用于可视化药物递送治疗脑肿瘤的研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[92,"微尺度细胞技术调控医用金纳米材料的合成和机理研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[93,"基于多尺度计算心脏模型的抗心律失常药物研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[94,"有向图中多机械臂系统的分布式协同控制研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[95,"复合海床地基中大直径钢筒基础稳定性研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[96,"基于监测数据的导管架式海洋结构数字孪生方法研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[97,"临近空间太阳能无人机机翼流固耦合机理及智能控制","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[98,"在轨操控逼近过程姿态轨道耦合高精度控制","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[99,"基于多相界面的小尺度仿生软体机器人磁控机理研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[100,"面向水下多任务自重构机器人系统及其形态规划和控制","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[101,"金属纳米线气凝胶基柔性复合钎料片及其自适应连接机理","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[102,"基于分层开裂与TRIP效应耦合作用的汽车用高强Q&amp;P钢增韧设计与强韧化机理研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[103,"含四元环药物分子中间体的光化学合成研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[104,"光催化微马达与油水界面的相互作用研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[105,"Mg3Bi2基半金属能带结构非对称性与热电性能优化","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[106,"用于锂空气电池的石墨烯负载金属单原子催化正极研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[107,"面向柔性电子集成器件的新型多功能取向碳纳米管复合纤维","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[108,"纳米颗粒增强型CrFeCoNi基高熵合金的组织调控和氢脆敏感性研究","哈尔滨工业大学（深圳）",{"v":60,"d":"60.00"}]
[109,"基于近地卫星观测的大气密度扰动特征研究","哈尔滨工业大学（深圳）",{"v":56,"d":"56.00"}]
[110,"基于微生物光电化学新理论的污水能源化与碳减排及碳增值转化调控机制研究","哈尔滨工业大学（深圳）",{"v":56,"d":"56.00"}]
[111,"灾害性空间天气太阳高能粒子事件研究","哈尔滨工业大学（深圳）",{"v":50,"d":"50.00"}]
[112,"Norrish-Yang光环化与电化学方法相结合的合成反应研究","哈尔滨工业大学（深圳）",{"v":50,"d":"50.00"}]
[113,"面向智能光网的多维度格式透明光性能监测机理及技术","哈尔滨工业大学（深圳）",{"v":40,"d":"40.00"}]
[114,"基于CT影像的新冠肺炎智能分析技术","哈尔滨工业大学（深圳）",{"v":40,"d":"40.00"}]
[115,"月壳磁异常对近月环境及月球科研站选址的影响研究","哈尔滨工业大学（深圳）",{"v":40,"d":"40.00"}]
[116,"真空紫外光解泳池尿素的效能、机理和副反应研究","哈尔滨工业大学（深圳）",{"v":40,"d":"40.00"}]
[117,"面向E级计算的高可扩展油藏模拟器及其并行求解算法研究","湖南大学深圳研究院",{"v":60,"d":"60.00"}]
[118,"高性能计算环境中的深度学习迭代优化体系结构研究","湖南大学深圳研究院",{"v":60,"d":"60.00"}]
[119,"大规模卷积神经网络异构并行算法及其在脑肿瘤智能分析与诊断中的应用","湖南大学深圳研究院",{"v":57.5,"d":"57.50"}]
[120,"治疗细菌感染的药物可再填充水凝胶的研究","湖南大学深圳研究院",{"v":55,"d":"55.00"}]
[121,"面向多源异构大数据智能处理的云雾协同计算","湖南大学深圳研究院",{"v":48,"d":"48.00"}]
[122,"大规模张量异构并行技术的研究","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[123,"基于二维范德华磁性异质结的自旋阀研究","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[124,"囊泡内GABA通过肠道固有免疫信号途径增强机体缺氧耐受能力的调控机制研究","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[125,"堆肥材料结合生物炭稳定修复深圳市茅洲河黑臭河道重金属污染底泥及改良底泥的生态资源利用","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[126,"高性能磁性粒子活体成像探针的开发及在肿瘤免疫治疗机制研究中的应用探索","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[127,"用于CO2电还原的Cu基金属间化合物纳米催化剂的精准制备、催化机理、与结构设计研究","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[128,"基于自由基发光体的电子新材料研究","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[129,"SPE电解水制氢中PtSn、IrRuSn纳米线的表面缺陷调控及梯度化电极构筑","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[130,"基于吸附构型调控的电催化α，β-不饱和醛选择性加氢研究","湖南大学深圳研究院",{"v":40,"d":"40.00"}]
[131,"TLR7/ MyD88/ NF-κB 通路在呼吸道病毒感染导致 IL-25高表达内型鼻息肉发病中的作用和机制研究","华中科技大学协和深圳医院",{"v":25,"d":"25.00"}]
[132,"FOXF1-miR-342-3p-EP300环路抑制糖尿病肾病进展的作用机制研究","华中科技大学协和深圳医院",{"v":20,"d":"20.00"}]
[133,"脂肪干细胞外泌体通过调节自噬改善糖尿病骨骼肌缺血病变的机制研究","华中科技大学协和深圳医院",{"v":20,"d":"20.00"}]
[134,"内源性大麻素系统CB1R/CB2R参与电针抑制银屑病瘙痒的神经生物学机制研究","华中科技大学协和深圳医院",{"v":20,"d":"20.00"}]
[135,"膈下迷走神经介导的脾脏TFF2在心脏骤停/心肺复苏术后全身免疫抑制中的作用","华中科技大学协和深圳医院",{"v":20,"d":"20.00"}]
[136,"基于深度学习和健康医疗大数据的深圳市老年人认知障碍及健康风险预测模型构建研究","华中科技大学协和深圳医院",{"v":20,"d":"20.00"}]
[137,"基于肠道菌群--胆汁酸--FXR信号通路探讨原花青素对妊娠糖尿病的影响和机制","华中科技大学协和深圳医院",{"v":20,"d":"20.00"}]
[138,"DAMPs通过TLRs/自噬/NETs通路介导创伤出血性休克肝脏损伤的机制研究","华中科技大学协和深圳医院",{"v":19,"d":"19.00"}]
[139,"TRPV2/PGC1α通路调控DRG神经元线粒体再生修复防治化疗神经病变的机制研究","华中科技大学协和深圳医院",{"v":16,"d":"16.00"}]
[140,"LncRNA&nbsp;H19/miR-324-3p/CAP轴抑制NF-κB通路限制支气管上皮细胞炎症改善哮喘的机制研究","华中科技大学协和深圳医院",{"v":13,"d":"13.00"}]
[141,"早产儿脑白质损伤超声智能诊断的临床研究","华中科技大学协和深圳医院",{"v":10,"d":"10.00"}]
[142,"火星在太阳风作用下的离子逃逸研究","南方科技大学",{"v":60,"d":"60.00"}]
[143,"超快太赫兹激光对物相调控的理论研究","南方科技大学",{"v":60,"d":"60.00"}]
[144,"高性能白光量子点发光二极管及其彩色像素化技术的研究","南方科技大学",{"v":60,"d":"60.00"}]
[145,"基于相分布及取向调控的高效率纯蓝光准二维钙钛矿发光二极管研究","南方科技大学",{"v":60,"d":"60.00"}]
[146,"高维回归模型无惩罚似然推断研究","南方科技大学",{"v":60,"d":"60.00"}]
[147,"有效提高性能的深度迁移学习技术研究","南方科技大学",{"v":60,"d":"60.00"}]
[148,"利用环境噪声对深圳沿海地区不良地质体进行人工智能识别","南方科技大学",{"v":60,"d":"60.00"}]
[149,"工业酶的体内进化系统开发","南方科技大学",{"v":60,"d":"60.00"}]
[150,"拟南芥鸟苷酸交换因子VPS9a参与JA信号途径调控植物主根发育的生物学机制研究","南方科技大学",{"v":60,"d":"60.00"}]
[151,"拟南芥雄配子体发育过程中染色质重编程及转录组重塑的机制解析","南方科技大学",{"v":60,"d":"60.00"}]
[152,"多药耐药性相关蛋白ABCC5的结构与功能研究","南方科技大学",{"v":60,"d":"60.00"}]
[153,"剪接抑制介导的染色质滞留调控拟南芥光形态建成的分子机制","南方科技大学",{"v":60,"d":"60.00"}]
[154,"利用单细胞组学技术研究三阴性乳腺癌细胞对PARP抑制剂的耐药机制","南方科技大学",{"v":60,"d":"60.00"}]
[155,"基因编码的DNA纳米药物用于肝细胞癌的靶向治疗","南方科技大学",{"v":60,"d":"60.00"}]
[156,"基于深度机器学习算法的深圳内涝特征机制解析与预报关键技术研发","南方科技大学",{"v":60,"d":"60.00"}]
[157,"基于多源立体数据同化的粤港澳大湾区臭氧模拟改进研究","南方科技大学",{"v":60,"d":"60.00"}]
[158,"影响大亚湾核电站生物爆发的区域海洋生态环境机制","南方科技大学",{"v":60,"d":"60.00"}]
[159,"基于大数据云服务体系的深圳市洪涝集合预报","南方科技大学",{"v":60,"d":"60.00"}]
[160,"mCRP适配体用于精准化改善来氟米特在类风湿性关节炎中治疗效果的研究","南方科技大学",{"v":60,"d":"60.00"}]
[161,"ATM诱导的代谢重编在神经退行性疾病中的作用机制","南方科技大学",{"v":60,"d":"60.00"}]
[162,"GLUT1通过MET促进肺癌脑转移的分子机制研究","南方科技大学",{"v":60,"d":"60.00"}]
[163,"GPRASP1甲基化促进前列腺癌进展与转移的分子机制","南方科技大学",{"v":60,"d":"60.00"}]
[164,"利用循环肿瘤细胞（CTC）模型研究Hippo信号通路介导的黑色素瘤抗药性机理","南方科技大学",{"v":60,"d":"60.00"}]
[165,"靶向EGFR的PROTAC小分子在肺癌中的作用机制研究","南方科技大学",{"v":60,"d":"60.00"}]
[166,"基于自然运动想象的步态识别算法研究","南方科技大学",{"v":60,"d":"60.00"}]
[167,"基于动态分析理论的快速超声三维测速方法","南方科技大学",{"v":60,"d":"60.00"}]
[168,"戊型肝炎病毒调控线粒体DNA促进病毒持续复制的机制研究","南方科技大学",{"v":60,"d":"60.00"}]
[169,"沉淀强化型镍基合金激光增材制造中组织各向异性及强化相特征同步调控热处理技术研发","南方科技大学",{"v":60,"d":"60.00"}]
[170,"基于连续纤维4D打印的形状记忆多稳态超材料结构-功能一体化设计方法研究","南方科技大学",{"v":60,"d":"60.00"}]
[171,"无芳基参与的轴手性骨架的设计与催化不对称构建","南方科技大学",{"v":60,"d":"60.00"}]
[172,"基于燃料电池的单原子电催化过程的理论模拟及催化剂理性设计","南方科技大学",{"v":60,"d":"60.00"}]
[173,"提高罗丹明基过渡金属配合物高活性氧生成能力的机理研究及应用","南方科技大学",{"v":60,"d":"60.00"}]
[174,"面向金属增材制造的微细球形颗粒增强金属基复合粉体材料短流程制备技术研究","南方科技大学",{"v":60,"d":"60.00"}]
[175,"原位光电协同作用下电致变色氧化物薄膜的离子反俘获研究","南方科技大学",{"v":60,"d":"60.00"}]
[176,"新型不对称转移氢化催化剂的设计、合成及在非天然糖醇及其类似物不对称合成中的应用研究","南方科技大学",{"v":60,"d":"60.00"}]
[177,"面向聚烯烃塑料回收和高性能化的共聚物策略","南方科技大学",{"v":60,"d":"60.00"}]
[178,"基于微合金化的抗氢脆高熵材料设计及其变形机理研究","南方科技大学",{"v":60,"d":"60.00"}]
[179,"基于有机催化芳烃极性翻转策略的芳烃C-H键高效转化","南方科技大学",{"v":60,"d":"60.00"}]
[180,"神经保护活性天然产物Illisimonin A的不对称全合成研究","南方科技大学",{"v":60,"d":"60.00"}]
[181,"基于结构函数法的三维集成封装芯片的无损热阻测试研究","南方科技大学",{"v":60,"d":"60.00"}]
[182,"具有全受体骨架的酰亚胺基n型聚合物材料研发与性能研究","南方科技大学",{"v":60,"d":"60.00"}]
[183,"水热条件下一氧化碳电化学还原制多碳产物","南方科技大学",{"v":60,"d":"60.00"}]
[184,"基于车桩网多端协同的电动汽车灵活储能资源群智管理研究","南方科技大学",{"v":60,"d":"60.00"}]
[185,"基于主客体相互作用调控的高纯度半导体性碳纳米管分离","南方科技大学",{"v":60,"d":"60.00"}]
[186,"面向可植入生物电子的水凝胶粘合界面构建与机理研究","南方科技大学",{"v":60,"d":"60.00"}]
[187,"基元化学反应的动力学研究和量子调控","南方科技大学",{"v":60,"d":"60.00"}]
[188,"高温高压燃气中爆轰等非常规燃烧模态的形成与发展机制","南方科技大学",{"v":60,"d":"60.00"}]
[189,"高发光效率近红外二区有机荧光材料的超分子构筑策略","南方科技大学",{"v":60,"d":"60.00"}]
[190,"基于相变与析出的纳米孪晶金属的制备与性能研究","南方科技大学",{"v":60,"d":"60.00"}]
[191,"钯催化烯丙基试剂的插羰环化反应","南方科技大学",{"v":60,"d":"60.00"}]
[192,"天然产物Solanoeclepin A的不对称全合成研究","南方科技大学",{"v":60,"d":"60.00"}]
[193,"有机催化芳基硅的不对称功能化","南方科技大学",{"v":60,"d":"60.00"}]
[194,"羧酸参与的一些不对称转化研究","南方科技大学",{"v":60,"d":"60.00"}]
[195,"弱溶剂化电解液在低温金属锂电池中的作用机制","南方科技大学",{"v":60,"d":"60.00"}]
[196,"四齿碳龙化合物用于C-N偶联反应制备仲胺及仲胺类药物","南方科技大学",{"v":60,"d":"60.00"}]
[197,"基于程控光化学反应的立体三维显示研究","南方科技大学",{"v":60,"d":"60.00"}]
[198,"可燃冰开采侵蚀土骨架机制和微生物矿化加固粉砂土方法研究","南方科技大学",{"v":58,"d":"58.00"}]
[199,"海上浮式风机基础非线性水动力学研究","南方科技大学",{"v":50,"d":"50.00"}]
[200,"面向深海采矿多金属结核区稀软沉积物承载性能及沉陷机理研究","南方科技大学",{"v":50,"d":"50.00"}]
[201,"基于多学科交叉的滑坡灾害监测预警技术研究","南方科技大学",{"v":40,"d":"40.00"}]
[202,"基于人工智能的注水诱发地震预警研究","南方科技大学",{"v":40,"d":"40.00"}]
[203,"餐厨垃圾与污水厂剩余污泥厌氧共消化工艺中微生物群落微米尺度空间结构及互作机理研究","南方科技大学",{"v":40,"d":"40.00"}]
[204,"应用创新科技深究深圳湾地区鸻鹬类候鸟活动规律及保护需求","南方科技大学",{"v":40,"d":"40.00"}]
[205,"粤港澳大湾区风暴潮灾害预警预报系统研究","南方科技大学",{"v":40,"d":"40.00"}]
[206,"新型污染物PFAS在深圳市水环境中的迁移转化机理研究及模型开发","南方科技大学",{"v":40,"d":"40.00"}]
[207,"可视化检测新型冠状病毒/甲型/乙型流感病毒核酸生物传感器的研究","南方科技大学",{"v":40,"d":"40.00"}]
[208,"铂单原子合金纳米框架的精准构造与电催化性质研究","南方科技大学",{"v":40,"d":"40.00"}]
[209,"基于外泌体(miR-30a/AIF-1)-程序性细胞死亡途径探讨TRPC6- Calcium/Calcineurin-NFAT通路活化在糖尿病肾脏疾病中作用机制","南方科技大学医院",{"v":30,"d":"30.00"}]
[210,"基于视觉识别6+骨折复位机器人基本原理及系统整合研究","南方科技大学医院",{"v":20,"d":"20.00"}]
[211,"脂肪外泌体lncRNA MALAT1通过下丘脑摄食中枢 YAP/PTEN/mTOR通路调控能量代谢的作用及机制","南方科技大学医院",{"v":20,"d":"20.00"}]
[212,"基于多迭代侧输出网络结构对乳腺癌新辅助化疗疗效评估与预测模型研究","南方科技大学医院",{"v":16,"d":"16.00"}]
[213,"肿瘤细胞趋化因子CCL5等调节CD8+ TILs的协同功能及上游调控机制研究","南方科技大学医院",{"v":14,"d":"14.00"}]
[214,"lncRNA-G018548招募多聚嘧啶通道结合蛋白 1 调控人牙髓干细胞成牙本质向分化的机制研究","南方医科大学深圳口腔医院（坪山）",{"v":12,"d":"12.00"}]
[215,"脓毒症时c-Myc促进巨噬细胞极化释放外泌体APN介导肺泡上皮细胞线粒体损伤的作用机制","南方医科大学深圳医院",{"v":57,"d":"57.00"}]
[216,"HMGB1/TLR4/IL-17轴与NLRP3炎症小体/Caspase-1通路介导的细胞焦亡在心肌缺血再灌注损伤中的作用及机制研究","南方医科大学深圳医院",{"v":30,"d":"30.00"}]
[217,"m6A修饰促进CircRNA HIPK3出核并影响CXCR4 mRNA稳定性调控脑梗死后血管新生的作用及机制研究","南方医科大学深圳医院",{"v":30,"d":"30.00"}]
[218,"核受体LRH-1促进神经内分泌前列腺癌发生和恶性进展的机制研究","南方医科大学深圳医院",{"v":30,"d":"30.00"}]
[219,"下肢外骨骼康复机器人对脑卒中恢复期患者运动皮层功能重建的有效性及机制研究","南方医科大学深圳医院",{"v":30,"d":"30.00"}]
[220,"基于影像组学的胰腺癌嗜神经生长、血管侵犯潜在因素的精准检测及预后预测策略和关键问题的研究","南方医科大学深圳医院",{"v":30,"d":"30.00"}]
[221,"接种新冠疫苗后血液相关免疫学指标及对蛋白标志物的调控","南方医科大学深圳医院",{"v":30,"d":"30.00"}]
[222,"尿液外泌体VTN激活TGF-β1 / Smad 信号通路参与神经源性膀胱患者膀胱纤维化机制研究","南方医科大学深圳医院",{"v":24,"d":"24.00"}]
[223,"内质网应激介导肺泡上皮细胞分泌TNC诱导M1型巨噬细胞极化促进脓毒症急性肺损伤的作用机制","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[224,"LEF1/TCF7信号通路在新生儿免疫功能低下中的作用 及机制研究","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[225,"CaV1.2激活介导内质网应激-细胞焦亡在糖尿病前期周围神经病变中的作用及机制","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[226,"AMD1依赖的多胺代谢对髓系白血病干细胞LSCs分化和干性维持的影响及应用","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[227,"高致死率毒素米酵菌酸毒物动力学和分子毒理学研究","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[228,"支链氨基酸代谢在幽门螺杆菌毒力蛋白CagA致胃癌中的作用与机制研究","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[229,"神经干细胞仿生微囊递送NeuroD1诱导胶质细胞向类神经元分化抗脑胶质瘤的研究","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[230,"Hsa_circ_0004083对衰老内皮祖细胞功能的调控作用及机制研究","南方医科大学深圳医院",{"v":20,"d":"20.00"}]
[231,"防侦察卫星窃听的星间激光通信混沌加密技术研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[232,"边缘计算环境下车联网智能服务部署的关键技术研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[233,"Wasserstein分布鲁棒优化的算法设计与应用","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[234,"靶向组胺H4受体改善应激诱导高血压的作用及中枢机制研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[235,"不同神经信息传递模式在海兔行为可变性中的功能及机制研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[236,"靶向烟酰胺核糖苷激酶NMRK2调控Xp11.2易位/TFE3基因融合相关性肾癌代谢适应的转化生物学研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[237,"金属有机框架材料结构调控及催化二氧化碳转化性能研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[238,"基于晶格氧活性正极材料的高效率低成本钠离子电池研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[239,"单原子-氧化物催化剂的17O固体核磁共振研究","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[240,"分子量子材料的计算方法和软件","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[241,"近红外有机热延迟发光材料及其在时间分辨荧光成像的应用","南京大学深圳研究院",{"v":60,"d":"60.00"}]
[242,"基于多层次语义推理的视频内容理解关键技术研究","南京大学深圳研究院",{"v":40,"d":"40.00"}]
[243,"基于拓扑薄膜材料的奇异物性和低功耗器件探索","南京大学深圳研究院",{"v":40,"d":"40.00"}]
[244,"新型铁-碳复合功能材料还原修复硝酸盐、卤代烃污染地下水研究","南京大学深圳研究院",{"v":40,"d":"40.00"}]
[245,"绿色强化混凝技术在地表水水质提升中的应用及其作用原理","南京大学深圳研究院",{"v":40,"d":"40.00"}]
[246,"锂离子电池健康感知型快充控制策略研究","南京大学深圳研究院",{"v":40,"d":"40.00"}]
[247,"民用雷达抗多用户干扰理论","南京航空航天大学深圳研究院",{"v":60,"d":"60.00"}]
[248,"基于密码技术和博弈论的机器学习隐私保护和安全关键技术研究","南京航空航天大学深圳研究院",{"v":40,"d":"40.00"}]
[249,"基于属性的新型公钥加密技术研究","南京航空航天大学深圳研究院",{"v":40,"d":"40.00"}]
[250,"航天黏附捕获机构的仿生创新设计与流固耦合黏附力学","南京航空航天大学深圳研究院",{"v":40,"d":"40.00"}]
[251,"基于一体化制备石墨烯纳米带与石墨烯电极的突触晶体管开发与可塑性研究","南开大学深圳研究院",{"v":60,"d":"60.00"}]
[252,"封装与焊接应力对高精度带隙基准电路影响的模型构建和补偿机制研究","南开大学深圳研究院",{"v":40,"d":"40.00"}]
[253,"深圳快速城市化进程对城市区域土壤蒸发及植被蒸腾影响机理研究","南开大学深圳研究院",{"v":40,"d":"40.00"}]
[254,"基于配位场协同增强机制的海水产氢催化剂设计研究","南开大学深圳研究院",{"v":40,"d":"40.00"}]
[255,"沙门氏菌与巨噬细胞在代谢水平上的互作机制研究","南开国际先进研究院（深圳福田）",{"v":60,"d":"60.00"}]
[256,"小延伸复合物（Little Elongation Complex）的装配与功能机制研究","南开国际先进研究院（深圳福田）",{"v":60,"d":"60.00"}]
[257,"足细胞中mTORC1的生理功能和分子机制研究","南开国际先进研究院（深圳福田）",{"v":60,"d":"60.00"}]
[258,"抗癌症干细胞先导化合物靶点探索与创新药物分子研究","南开国际先进研究院（深圳福田）",{"v":60,"d":"60.00"}]
[259,"合理设计溶瘤病毒及其对胰腺导管癌免疫微环境的影响与应用","南开国际先进研究院（深圳福田）",{"v":59,"d":"59.00"}]
[260,"基于网络表示学习和超网络模型的多变量时间序列相关性研究","清华大学深圳国际研究生院",{"v":60,"d":"60.00"}]
[261,"能源互联网环境下虚拟电厂与配电网协同调度研究","清华大学深圳国际研究生院",{"v":60,"d":"60.00"}]
[262,"基于无机有机复合材料的负极集流体/电解液界面调控技术在无负极锂电池中的应用研究","清华大学深圳国际研究生院",{"v":60,"d":"60.00"}]
[263,"磷酸铵镁微生物矿化对氮磷处置过程中四环素的响应机制及其调控因素研究","清华大学深圳国际研究生院",{"v":59,"d":"59.00"}]
[264,"主动故障诊断方法的最小可检测与可分离故障问题研究","清华大学深圳国际研究生院",{"v":54,"d":"54.00"}]
[265,"泡沫碳化硅陶瓷填料孔隙内二氧化碳水合物相变机理研究","清华大学深圳国际研究生院",{"v":40,"d":"40.00"}]
[266,"基于超构材料的声学隐身器件研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[267,"基于表面等离激元增强效应的太赫兹石墨烯波导调制器研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[268,"仿生抗氧化共组装制剂的动脉粥样硬化治疗策略及机制研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[269,"可溶性CSF1R在阿尔茨海默病中的作用研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[270,"Exo70促进卵巢癌顺铂耐药的机制研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[271,"介孔蜂海绵骨针辅助光动力免疫疗法治疗转移性黑色素瘤","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[272,"新型磁流变进动抛光理论及大口径光学元件的中频误差控制","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[273,"具有可修饰空腔的人工纳米孔的构建及其在DNA跨膜传输中的应用研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[274,"Si-Cu-Sn微合金化精炼制备高纯多晶硅的关键技术研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[275,"双组分无掺杂有机空穴传输材料协同导电机制及光伏性能研究","厦门大学深圳研究院",{"v":60,"d":"60.00"}]
[276,"功能化树枝状空穴传输材料的构筑及其在非掺杂型钙钛矿器件中的应用","厦门大学深圳研究院",{"v":52,"d":"52.00"}]
[277,"基于16SrDNA基因测序和NO-cGMP信号通路针刺大鼠上星、风府穴 治疗其CUMS抑郁样行为的作用机制研究","厦门大学深圳研究院",{"v":40,"d":"40.00"}]
[278,"Cu-Zn-Sn基应变玻璃单晶的设计、制备及功能特性研究","厦门大学深圳研究院",{"v":40,"d":"40.00"}]
[279,"车联网中高效可靠正交时频空间无线通信技术研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[280,"2英寸高质量AlN单晶生长及基器件应用研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[281,"梭菌基因组操纵技术与天然药物生产体系研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[282,"肿瘤细胞中GSDME与EGFR互作机制与功能研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[283,"外泌体介导的GXYLT2糖基化修饰Notch1-YAP信号轴靶向调控血管外周前脂肪 细胞与血管外膜成纤维细胞对话和血管重构的机制研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[284,"Homoharringtonine降解PD-L1及调控肿瘤免疫的分子机制","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[285,"新型亚型选择性PARP抑制剂的设计合成、活性评价与作用机制研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[286,"Ga2O3单晶自绝缘层形成机理与器件耐压增强应用基础研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[287,"纳米铝化物粒子网原位构筑机制与耐热高强铝合金的研究","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[288,"新能源并网变流器集群及智能控制关键理论与技术","山东大学深圳研究院",{"v":60,"d":"60.00"}]
[289,"极端海洋环境高功率密度波浪能直驱磁阻发电装备关键技术","山东大学深圳研究院",{"v":50,"d":"50.00"}]
[290,"高效高功率高重频真空紫外光源关键技术研究","山东大学深圳研究院",{"v":40,"d":"40.00"}]
[291,"基于高Al组分AlGaN的垂直结构功率器件研究","山东大学深圳研究院",{"v":40,"d":"40.00"}]
[292,"电子束微区熔化技术调控高强高韧非晶复合材料微观结构和力学性能的研究","山东大学深圳研究院",{"v":40,"d":"40.00"}]
[293,"大视场双光子成像引导的乏氧肿瘤光动力治疗研究","上海交通大学深圳研究院",{"v":40,"d":"40.00"}]
[294,"静态和旋转条件航空发动机涡轮叶片高性能旋流-气膜复合冷却机理研究","上海交通大学深圳研究院",{"v":40,"d":"40.00"}]
[295,"城市声学环境智能感知关键技术研究","深港产学研基地(北京大学香港科技大学深圳研修院）",{"v":40,"d":"40.00"}]
[296,"深圳市主要工业源含氧挥发性有机物排放特征与反应活性研究","深港产学研基地(北京大学香港科技大学深圳研修院）",{"v":40,"d":"40.00"}]
[297,"超声靶向抗氧化复合药物用于修复中枢神经细胞的机制研究","深圳北京大学香港科技大学医学中心",{"v":30,"d":"30.00"}]
[298,"基于JAK/STAT/miR-146信号轴调节巨噬细胞功能探讨清肺理痰方治疗细菌感染性急性肺损伤的作用机制","深圳北京中医药大学研究院",{"v":60,"d":"60.00"}]
[299,"大规模图像数据的二值特征提取","深圳大学",{"v":60,"d":"60.00"}]
[300,"数据驱动辅助的边缘计算智能化任务卸载与多维资源配置优化","深圳大学",{"v":60,"d":"60.00"}]
[301,"多粒度模糊知识推理理论及应用","深圳大学",{"v":60,"d":"60.00"}]
[302,"面向下一代光通信的石墨烯-混合SNIMS等离子体光波导及器件研究","深圳大学",{"v":60,"d":"60.00"}]
[303,"数据与应用共驱的大规模加权图高效构造关键技术研究","深圳大学",{"v":60,"d":"60.00"}]
[304,"面向B5G的高系统效能无人机通信技术研究","深圳大学",{"v":60,"d":"60.00"}]
[305,"面向大数据计算的复杂性度量和样本容量估计理论与方法研究","深圳大学",{"v":60,"d":"60.00"}]
[306,"基于忆阻类脑计算的优化电路关键技术及其应用","深圳大学",{"v":60,"d":"60.00"}]
[307,"高时空分辨的红外超快相位成像技术及其应用研究","深圳大学",{"v":60,"d":"60.00"}]
[308,"基于同步泵浦的3.5μm中红外超短锁模脉冲的产生和测量研究","深圳大学",{"v":60,"d":"60.00"}]
[309,"基于多源大数据驱动的可持续制造供应链博弈模型","深圳大学",{"v":60,"d":"60.00"}]
[310,"新一代无线通信系统的物理层认证算法研究","深圳大学",{"v":60,"d":"60.00"}]
[311,"基于自组织行为分析的交通枢纽疏散管理数字孪生研究-以深圳北站为例","深圳大学",{"v":60,"d":"60.00"}]
[312,"活细胞内多运动目标同时四维追踪方法和系统","深圳大学",{"v":60,"d":"60.00"}]
[313,"基于单对激发-损耗激光实现低信道串扰STED三色活细胞超分辨成像的研究","深圳大学",{"v":60,"d":"60.00"}]
[314,"基于核壳型半导体量子点的超快速非易失性存储器研究","深圳大学",{"v":60,"d":"60.00"}]
[315,"面向5G系统的高分辨上行CFO估计技术研究","深圳大学",{"v":60,"d":"60.00"}]
[316,"脉冲展宽型高时间分辨X光探测技术研究","深圳大学",{"v":60,"d":"60.00"}]
[317,"飞控程序中多重精度运算正确性形式化验证","深圳大学",{"v":60,"d":"60.00"}]
[318,"面向职业健康风险预测预警的多方隐私数据学习技术研究","深圳大学",{"v":60,"d":"60.00"}]
[319,"面向内嵌闪存的叠瓦式磁盘的写放大及尾延迟优化技术研究","深圳大学",{"v":60,"d":"60.00"}]
[320,"0-1矩阵幂的组合性质","深圳大学",{"v":60,"d":"60.00"}]
[321,"面向多功能人机交互显示应用的光探测型发光器件技术研究","深圳大学",{"v":60,"d":"60.00"}]
[322,"面向基于距离相似性查询的完全线性划分树研究","深圳大学",{"v":60,"d":"60.00"}]
[323,"饮用水溴代消毒副产物还原去除机制及深度净化应用研究","深圳大学",{"v":60,"d":"60.00"}]
[324,"面向低蛋白血症快速检测的荧光探针分子的开发","深圳大学",{"v":60,"d":"60.00"}]
[325,"凝集素受体 DCIR调控Syk介导的抗真菌免疫应答的作用及机制研究","深圳大学",{"v":60,"d":"60.00"}]
[326,"资源匮乏抑制亲社会行为的神经机制及其神经调节技术","深圳大学",{"v":60,"d":"60.00"}]
[327,"人工智能背景下的人机协同机制研究","深圳大学",{"v":60,"d":"60.00"}]
[328,"基于大脑皮层功能连接组的焦虑神经反馈调节技术","深圳大学",{"v":60,"d":"60.00"}]
[329,"可替代草甘膦的新型高效低毒灭生性除草剂的研制","深圳大学",{"v":60,"d":"60.00"}]
[330,"微纳塑料经口毒性研究及食品污染防控标准的建立","深圳大学",{"v":60,"d":"60.00"}]
[331,"关于一株海洋细菌抗食源性致病菌生物膜的有效成分的分离鉴定、活性评价及分子机制研究","深圳大学",{"v":60,"d":"60.00"}]
[332,"通过叶绿体基因组工程在莱茵衣藻中合成虾青素的研究","深圳大学",{"v":60,"d":"60.00"}]
[333,"面向机器人自主导航的类脑视觉场景理解与实时位置计算方法","深圳大学",{"v":60,"d":"60.00"}]
[334,"一氧化氮信号通路在环保型抗污损化合物处理过程中的应答机理研究","深圳大学",{"v":60,"d":"60.00"}]
[335,"靶向IL-1β特异性组蛋白修饰的结核病控制新策略研究","深圳大学",{"v":60,"d":"60.00"}]
[336,"KCNE2 调节心脏肌浆网内稳态在糖尿病心肌病中的作用机制研究","深圳大学",{"v":60,"d":"60.00"}]
[337,"KChIP2棕榈酰化—去棕榈酰化循环的分子机制及其在心肌肥大中的作用研究","深圳大学",{"v":60,"d":"60.00"}]
[338,"新型肝脂滴蛋白17β-HSD13通过调控脂代谢参与非酒精性脂肪性肝炎脂代谢紊乱及机制研究","深圳大学",{"v":60,"d":"60.00"}]
[339,"心理应激通过外周Kisspeptin/GPR54系统对卵巢功能的调控作用及机制研究","深圳大学",{"v":60,"d":"60.00"}]
[340,"靶向HDAC11抗糖尿病肾损伤作用及其分子机制研究","深圳大学",{"v":60,"d":"60.00"}]
[341,"糖尿病肾病治疗新型靶标-肾小管细胞HMGCS2分子的发现与验证","深圳大学",{"v":60,"d":"60.00"}]
[342,"适应慢性寒冷挑战生物钟重置肝脏代谢节律维持体温的机制研究","深圳大学",{"v":60,"d":"60.00"}]
[343,"靶向潜在自噬流调控因子SigmaR1抗糖尿病视网膜tau蛋白病变的作用机制研究","深圳大学",{"v":60,"d":"60.00"}]
[344,"线粒体膜电位相关蛋白VDAC1在AD胆碱能神经损伤的作用和机制","深圳大学",{"v":60,"d":"60.00"}]
[345,"NO-cGMP信号通路对脊髓前馈抑制环路的调控及其在触诱发痛过程中的机制研究","深圳大学",{"v":60,"d":"60.00"}]
[346,"鼻腔泪囊吻合术相关解剖结构交互式虚拟学习系统的创建","深圳大学",{"v":60,"d":"60.00"}]
[347,"中药天花粉蛋白生物矿化靶向材料的合成及其抑制口腔鳞癌的效果研究","深圳大学",{"v":60,"d":"60.00"}]
[348,"突变型SPOP E3连接酶促进雄激素生成和前列腺癌进展的机制及临床意义","深圳大学",{"v":60,"d":"60.00"}]
[349,"胶质瘤浸润边界生物学特征及提高手术切除率的转化医学研究","深圳大学",{"v":60,"d":"60.00"}]
[350,"BRCA1缺失激活PDGFRβ信号通路增加乳腺癌转移起始细胞的机制研究","深圳大学",{"v":60,"d":"60.00"}]
[351,"肿瘤相关巨噬细胞在外周血来源的单细胞多组学研究","深圳大学",{"v":60,"d":"60.00"}]
[352,"基于肿瘤能量代谢调控的多功能纳米诊疗剂的构建与应用研究","深圳大学",{"v":60,"d":"60.00"}]
[353,"丝精氨酸蛋白激酶1非激酶结构域在T790M突变NSCLC 促进EGFR-TKIs耐药的机制研究和相关抑制剂的开发","深圳大学",{"v":60,"d":"60.00"}]
[354,"基于磁纳米探针的超声多模态成像方法研究","深圳大学",{"v":60,"d":"60.00"}]
[355,"携AGTR1抗体靶向超声微血管成像诊断卵巢癌的实验研究","深圳大学",{"v":60,"d":"60.00"}]
[356,"基于深度影像组学MRI定量解码肝细胞癌微血管侵犯的研究","深圳大学",{"v":60,"d":"60.00"}]
[357,"Lamin A-CK2相关基因组不稳定性对心肌缺血损伤的影响机制及其临床关联性研究","深圳大学",{"v":60,"d":"60.00"}]
[358,"基于核酸适配体与磁性纳米微球的新型冠状病毒快速识别与分离机制研究","深圳大学",{"v":60,"d":"60.00"}]
[359,"DNA甲基化联合基因突变对结直肠腺瘤早期诊断和癌变风险预测研究","深圳大学",{"v":60,"d":"60.00"}]
[360,"不同代谢肥胖危险因素暴露长期趋势与2型糖尿病发病关系的队列研究","深圳大学",{"v":60,"d":"60.00"}]
[361,"灵芝活性成分抑制食管癌细胞自噬及增强顺铂敏感性的作用及其机制研究","深圳大学",{"v":60,"d":"60.00"}]
[362,"基于PINK1/Parkin通路探讨熄风定颤胶囊优化方对帕金森病模型小鼠线粒体自噬及线粒体质量的调控机制","深圳大学",{"v":60,"d":"60.00"}]
[363,"基于结构的靶向SIRT3小分子抑制剂的合成及抗急性髓系白血病的作用机制研究","深圳大学",{"v":60,"d":"60.00"}]
[364,"Laxiflorin B通过靶向ERK负性调控ERK/AREG(EREG)/EGFR信号通路抑制肺癌细胞生长和克服EGFR-TKIs耐药的作用机制研究","深圳大学",{"v":60,"d":"60.00"}]
[365,"城区爆破施工减振孔的减振隔振机理及邻近建(构)筑物减振效果研究","深圳大学",{"v":60,"d":"60.00"}]
[366,"病房室内病毒飞沫空气传播机理及防控方法研究","深圳大学",{"v":60,"d":"60.00"}]
[367,"仿生花型管式水凝胶海水淡化太阳能蒸发器的制备与应用","深圳大学",{"v":60,"d":"60.00"}]
[368,"基于大湾区地域特征的新型绿色节能材料与结构体系研究","深圳大学",{"v":60,"d":"60.00"}]
[369,"基坑开挖对紧邻地铁盾构隧道结构的影响及变形主动控制研究","深圳大学",{"v":60,"d":"60.00"}]
[370,"纳米发电机三维纳米金属网格电极脱合金复合加工机理及稳定性研究","深圳大学",{"v":60,"d":"60.00"}]
[371,"粤港澳大湾区典型钢结构高层建筑风致非线性动力响应特性研究","深圳大学",{"v":60,"d":"60.00"}]
[372,"智能化可穿戴远程跌倒风险评估和老年人跌倒预防","深圳大学",{"v":60,"d":"60.00"}]
[373,"利用天空辐射制冷蓄冷调节室内外热环境及节能研究","深圳大学",{"v":60,"d":"60.00"}]
[374,"轻质高强韧高熵合金强化微点阵基元仿竹序构复合材料及其机翼复合结构研究","深圳大学",{"v":60,"d":"60.00"}]
[375,"微型热式流量传感器的CMOS单片集成技术及其超低检测极限优化机制研究","深圳大学",{"v":60,"d":"60.00"}]
[376,"层阻塞可变刚度软体手的多模态触觉感知与力反馈交互控制研究","深圳大学",{"v":60,"d":"60.00"}]
[377,"纳米粒子@石墨烯碳膜诱导的近零磨合超低摩擦原理研究","深圳大学",{"v":60,"d":"60.00"}]
[378,"手性过渡金属氧化物的超快动力学及其二次谐波产生效应研究","深圳大学",{"v":60,"d":"60.00"}]
[379,"新型氧化石墨烯渗透汽化脱盐复合膜的制备及分离机制研究","深圳大学",{"v":60,"d":"60.00"}]
[380,"配位驱动自组装构筑圆偏振发光材料及其光电性能研究","深圳大学",{"v":60,"d":"60.00"}]
[381,"以(氘)水为(氘)氢源制备高附加值化学品的绿色合成关键技术","深圳大学",{"v":60,"d":"60.00"}]
[382,"定向转化策略调控铌基氮氧化物表面缺陷和晶体取向用于改善太阳能光催化析氢研究","深圳大学",{"v":60,"d":"60.00"}]
[383,"新型圆偏振发光材料的设计、光学性质及刺激响应性研究","深圳大学",{"v":60,"d":"60.00"}]
[384,"基于短肽纳米技术的高性能类脑智能计算器件","深圳大学",{"v":60,"d":"60.00"}]
[385,"用于全固态金属锂电池抗锂穿刺界面修饰的金属掺杂硫系玻璃固体电解质薄膜研究","深圳大学",{"v":60,"d":"60.00"}]
[386,"固态复合电解质“胶”的构建方法、界面问题及其性能研究","深圳大学",{"v":60,"d":"60.00"}]
[387,"基于纳米金形成的细菌药敏快速可视化分析方法研究","深圳大学",{"v":60,"d":"60.00"}]
[388,"可控构筑双活性中心CO2串联还原催化剂及其催化机理研究","深圳大学",{"v":60,"d":"60.00"}]
[389,"PEO基固态电解质改性研究与固态锂电池应用","深圳大学",{"v":60,"d":"60.00"}]
[390,"卤化物二维范德华晶体的磁性调控与多铁性研究","深圳大学",{"v":60,"d":"60.00"}]
[391,"应用于有效治理赤潮的可降解碳点的设计及制备","深圳大学",{"v":60,"d":"60.00"}]
[392,"基于负膨胀材料的燃料电池热机械稳定策略开发及作用机理研究","深圳大学",{"v":59,"d":"59.00"}]
[393,"高灵敏光纤激光氢气传感器阵列的飞秒激光制备及偏振调控技术","深圳大学",{"v":40,"d":"40.00"}]
[394,"基于深度学习的WebShell恶意软件检测模型的健壮性研究","深圳大学",{"v":40,"d":"40.00"}]
[395,"自籽晶氮化铝晶体生长的成核机制研究","深圳大学",{"v":40,"d":"40.00"}]
[396,"高可靠异构自组织无人蜂群网络通信与组网技术研究","深圳大学",{"v":40,"d":"40.00"}]
[397,"广义实数表示中相关问题研究","深圳大学",{"v":40,"d":"40.00"}]
[398,"基于P4的DDoS攻击检测算法和智能加速模型研究","深圳大学",{"v":40,"d":"40.00"}]
[399,"结构光复用通信与全光信息处理基础问题与关键技术研究","深圳大学",{"v":40,"d":"40.00"}]
[400,"光致载流子动态变化机理研究与增材制造光电器件应用","深圳大学",{"v":40,"d":"40.00"}]
[401,"超构表面矢量光场模式离轴调控机理及复用通信","深圳大学",{"v":40,"d":"40.00"}]
[402,"深度聚类算法及应用研究","深圳大学",{"v":40,"d":"40.00"}]
[403,"自适应低秩-稀疏分解引导的复杂场景运动目标检测研究","深圳大学",{"v":40,"d":"40.00"}]
[404,"金属声敏药物用于肿瘤声动力精准治疗及其机制的研究","深圳大学",{"v":40,"d":"40.00"}]
[405,"磷酸组氨酸衍生物的定位修饰：生物探针和染色质动态调控","深圳大学",{"v":40,"d":"40.00"}]
[406,"退化红树林的生态修复质量无人机遥感监测","深圳大学",{"v":40,"d":"40.00"}]
[407,"在三维超分辨及单细胞水平研究纳米脂筏在胚胎干细胞分化过程的结构变化及所起功能","深圳大学",{"v":40,"d":"40.00"}]
[408,"寄生性真菌在深圳市毗邻海域典型藻华事件演替中可能的调控作用研究","深圳大学",{"v":40,"d":"40.00"}]
[409,"海水腐蚀与动力扰动耦合作用下海底隧道围岩动态疲劳破坏机制","深圳大学",{"v":40,"d":"40.00"}]
[410,"生物炭负载 Z 型光催化剂的开发及在废水抗生素降解和制氢的应用","深圳大学",{"v":40,"d":"40.00"}]
[411,"面向无废城市建设的深圳市生活垃圾集成资源化环境负荷解析与环境影响优化研究","深圳大学",{"v":40,"d":"40.00"}]
[412,"肠道酪氨酸脱羧酶表达菌及其代谢物促进炎症性肠病的作用研究","深圳大学",{"v":40,"d":"40.00"}]
[413,"去泛素化酶USP43负向调控抗病毒天然免疫应答及其机制研究","深圳大学",{"v":40,"d":"40.00"}]
[414,"粉尘螨新过敏原鉴定方法学创新及新发现Derf39致敏新机制的研究","深圳大学",{"v":40,"d":"40.00"}]
[415,"HIF-1a在不同氧条件下视网膜色素上皮细胞的表达和在近视中的作用机制","深圳大学",{"v":40,"d":"40.00"}]
[416,"脓毒症时高迁移率族蛋白B1对血管内皮糖衣包被和内皮通透性的影响及机制的研究","深圳大学",{"v":40,"d":"40.00"}]
[417,"miR-29b 通过IGF1/PI3K/AKT信号通路调控肌肉减少症（sarcopenia）发病的机制研究","深圳大学",{"v":40,"d":"40.00"}]
[418,"miR-204-5p调控SHP2对AKI-CKD转归中的作用及机制","深圳恒生医院",{"v":20,"d":"20.00"}]
[419,"安全非易失内存系统的高效元数据管理研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[420,"面向CMOS单片集成的近红外II区量子点光电探测和成像研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[421,"联邦学习中多方协同零日攻击的主动感知与防御安全技术研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[422,"光电融合谐振型硅光复用/解复用波长锁定芯片研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[423,"面向紫外-可见-短波红外应用的超宽光谱TMDC/Ge异质结光电探测器","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[424,"脐带MSC来源细胞外囊泡延缓机体衰老的调控网络方法和机制研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[425,"Calpain介导GSK-3β活性在AD发病机理中的研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[426,"LINC00993促进METTL14介导的m6A甲基化修饰在前列腺癌去势抵抗中的作用机制研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[427,"基于“S100B-RAGE”分子识别的细胞膜仿生NBD多肽/纳米金递释系统克服脑胶质瘤放疗抵抗与预防复发的机制研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[428,"基于工程化巨噬细胞的心脏移植排斥反应诊疗研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[429,"基于磁纳米标记高次谐波效应的病毒现场快检方法","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[430,"复杂零件三维测量中顾及全局约束的累积误差建模和在线优化方法","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[431,"新型智能化海洋低频信号探测技术研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[432,"二维半导体/Weyl半金属范德华异质结远红外光电响应调控与机理研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[433,"万小时寿命高效反式钙钛矿太阳电池关键技术研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[434,"具有大电流长循环电解水析氢性能的三维分级孔道 电极的3D打印制造","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[435,"非层状二维钼基金属化合物材料的绿色制备及其电解水制氢机理研究","深圳华中科技大学研究院",{"v":60,"d":"60.00"}]
[436,"5G通信频段高移动场景信道预测方法研究","深圳华中科技大学研究院",{"v":40,"d":"40.00"}]
[437,"具有健康意识的固体氧化物燃料电池系统高效长寿协同控制研究","深圳华中科技大学研究院",{"v":40,"d":"40.00"}]
[438,"微纳表面结构动态精密测量技术与系统研究","深圳华中科技大学研究院",{"v":40,"d":"40.00"}]
[439,"当归活性成分欧当归内酯通过干预细胞焦亡途径缓解炎性肠病的作用及机制研究","深圳技术大学",{"v":60,"d":"60.00"}]
[440,"新型超硬/硬质、超强过渡金属硼化物高熵陶瓷的高温高压制备、结构与性能调控","深圳技术大学",{"v":60,"d":"60.00"}]
[441,"时空复杂场景的地铁运营大数据价值发现模型与方法","深圳技术大学",{"v":40,"d":"40.00"}]
[442,"手性等离激元纳腔构筑及其对二维半导体能谷自旋的调控研究","深圳京鲁计算科学应用研究院",{"v":60,"d":"60.00"}]
[443,"高通量筛选打破肺癌免疫抑制微环境的新靶点","深圳罗兹曼国际转化医学研究院",{"v":60,"d":"60.00"}]
[444,"成纤维细胞激活蛋白自身抗体在肺纤维化辅助诊断及靶向治疗中的应用","深圳罗兹曼国际转化医学研究院",{"v":40,"d":"40.00"}]
[445,"酶响应型双靶向荧光功能肽的构筑及其自组装抗癌应用研究","深圳罗兹曼国际转化医学研究院",{"v":40,"d":"40.00"}]
[446,"结构超滑体系速率-状态摩擦行为研究","深圳清华大学研究院",{"v":60,"d":"60.00"}]
[447,"3D打印真皮材料对创面血管化及瘢痕的影响及机制研究","深圳清华大学研究院",{"v":40,"d":"40.00"}]
[448,"基于超声振动催化耦合作用的碳化硅多尺度高效去除及光滑原子台阶创成机制","深圳清华大学研究院",{"v":40,"d":"40.00"}]
[449,"重楼皂苷Ⅱ基于外泌体miRNA-21调控PI3K/Akt/mTOR信号通路抑制非小细胞肺癌增殖转移机制研究","深圳市宝安纯中医治疗医院",{"v":20,"d":"20.00"}]
[450,"基于新型固相微萃取-HPLC和外泌体miRNA对蒸附片与姜附子的“药动-药效”研究","深圳市宝安纯中医治疗医院",{"v":20,"d":"20.00"}]
[451,"基于磁性固态纳米孔特异性提取外泌体在鼻咽癌早期诊断中的应用","深圳市宝安区福永人民医院",{"v":13,"d":"13.00"}]
[452,"Annexin A5调控子宫内膜蜕膜化在早期妊娠丢失中的作用及机制研究","深圳市宝安区妇幼保健院",{"v":20,"d":"20.00"}]
[453,"MXD1通过调节ARF6的表达调控外周血经典型单核细胞吞噬功能及其与早产儿B族链球菌感染致病的关系","深圳市宝安区妇幼保健院",{"v":20,"d":"20.00"}]
[454,"建立婴儿发育性髋关节发育不良的超声AI辅助诊断模型","深圳市宝安区妇幼保健院",{"v":13,"d":"13.00"}]
[455,"儿童青少年健康指数及心理行为健康的社会生态危险因素模型研究","深圳市宝安区疾病预防控制中心",{"v":20,"d":"20.00"}]
[456,"室内游泳场馆三卤甲烷暴露特征及人群致癌风险评价研究","深圳市宝安区疾病预防控制中心",{"v":15,"d":"15.00"}]
[457,"亚油酸及其代谢模式对2型糖尿病的影响及机制研究","深圳市宝安区慢性病防治院",{"v":13,"d":"13.00"}]
[458,"靶向病理胶原缓释谷氨酰胺募集关节内Gdf5谱系祖细胞修复关节软骨缺损的机制研究","深圳市宝安区人民医院",{"v":30,"d":"30.00"}]
[459,"骨髓间充质干细胞外泌体对新生大鼠肺发育不良的修复作用探讨","深圳市宝安区人民医院",{"v":20,"d":"20.00"}]
[460,"Rab1a调控巨噬细胞胞葬作用影响脓毒症肺损伤恢复的机制研究","深圳市宝安区人民医院",{"v":20,"d":"20.00"}]
[461,"基于大尺度网络的针刺干预遗忘型轻度认知障碍合并失眠症的机制研究","深圳市宝安区人民医院",{"v":12,"d":"12.00"}]
[462,"基于Reason模型的“互联网+护理服务”护士风险因素识别及防控体系构建","深圳市宝安区人民医院",{"v":10,"d":"10.00"}]
[463,"基于代谢组学和转录组学技术解析长春花干细胞高含量阿玛碱、长春碱形成的分子机制","深圳市宝安区石岩人民医院",{"v":20,"d":"20.00"}]
[464,"circTAF4B促进膀胱癌发生发展的分子机制研究及其初步临床应用","深圳市宝安区松岗人民医院",{"v":20,"d":"20.00"}]
[465,"PAIP1结合并稳定MCL1mRNA驱动肝癌索拉非尼耐药及其作为诊断标志物研究","深圳市宝安区中心医院",{"v":20,"d":"20.00"}]
[466,"超早期面体针疗法调节vPAG-下丘脑神经环路中DA神经元P2RX7表达改善颅脑创伤性昏迷的机制研究","深圳市宝安区中心医院",{"v":20,"d":"20.00"}]
[467,"穴位埋线调节绝经后骨量减少的靶向代谢组学研究","深圳市宝安区中医院",{"v":30,"d":"30.00"}]
[468,"夹脊电针通过促进外泌体递送miR-34a-5p抑制自噬介导的小胶质细胞M1型极化治疗SCI的机制研究","深圳市宝安区中医院",{"v":20,"d":"20.00"}]
[469,"VEGF/P-gp介导十二井穴放血增强脑组织药物富集效应及机制研究","深圳市宝安区中医院",{"v":20,"d":"20.00"}]
[470,"基于PI3K/Akt/mTOR信号通路探讨药根碱干预T790M突变非小细胞肺癌的机制","深圳市宝安区中医院",{"v":20,"d":"20.00"}]
[471,"基于TrkB/ERK通路研究针刺调控脑梗死大鼠神经发生和突触可塑性重构的分子新机制","深圳市宝安区中医院",{"v":10,"d":"10.00"}]
[472,"蜂针通过抑制Hippo信号通路促进滑膜成纤维细胞凋亡干预类风湿关节炎的机制研究","深圳市宝安区中医院",{"v":10,"d":"10.00"}]
[473,"深圳近海海水及海产品中致病弧菌时空分布及病原学特征研究","深圳市大鹏新区公共卫生管理服务中心（深圳市大鹏新区疾病预防控制中心）",{"v":10,"d":"10.00"}]
[474,"脂肪源外泌体miRNAs抑制精原干细胞分化在肥胖导致的生殖损伤中的作用及机制","深圳市大鹏新区南澳人民医院",{"v":20,"d":"20.00"}]
[475,"cHASI-VHL多肽清除Aβ40促血小板对脑淀粉样病变血管内皮损伤修复的作用及分子机制研究","深圳市第二人民医院",{"v":31,"d":"31.00"}]
[476,"Schroth疗法对改善青少年特发性脊柱侧凸进展的远期疗效及生物力学机制研究","深圳市第二人民医院",{"v":30,"d":"30.00"}]
[477,"骨性关节炎关节液来源间充质干/祖细胞功能亚群解析及其与病变关节软骨相互作用与机制研究","深圳市第二人民医院",{"v":30,"d":"30.00"}]
[478,"免疫细胞膜促进碳基纳米酶对鼻咽癌催化治疗的研究","深圳市第二人民医院",{"v":30,"d":"30.00"}]
[479,"NR4A1基因的增强子及其eRNA在结直肠癌发生和转移中的作用机制","深圳市第二人民医院",{"v":30,"d":"30.00"}]
[480,"细菌仿生金纳米粒介导免疫细胞载体的在体构建新策略及其光热增强的“内应式”靶向抗肿瘤免疫效应研究","深圳市第二人民医院",{"v":30,"d":"30.00"}]
[481,"LncRNA-MALAT1与miR-5195-3p相互作用 促进Sema3A表达调控鼻咽癌骨转移的作用和分子机制研究","深圳市第二人民医院",{"v":25,"d":"25.00"}]
[482,"雌激素受体β- TGFβ1-肾间质纤维化在糖尿病肾脏疾病中的作用和机制","深圳市第二人民医院",{"v":23,"d":"23.00"}]
[483,"脂肪干细胞外泌体miR-145抑制海绵体平滑肌细胞RhoA/ROCK1通路改善糖尿病大鼠勃起功能的机制研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[484,"骨靶向光热仿生纳米载体的制备及其在骨质疏松治疗中的研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[485,"βPIX介导KCC2与GABAA受体的协同调控参与癫痫发病的机制研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[486,"基于多核微胶囊的脑类组装体构建及其在精神分裂症研究中的应用","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[487,"神经干祖细胞通过分泌piRNA-PIWIL2复合物抵御脑内病毒感染的机制研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[488,"基于反蛋白石结构制备双层水凝胶补片用于角膜缺损修复","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[489,"基于外泌体仿生纳米递药系统用于口腔癌的联合治疗及其机制研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[490,"CIRP转录后调控SMO促使骨肉瘤Hh/SMO/Gli1通路异常激活和侵袭转移的分子机制研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[491,"双重靶向纳米药物协同“饥饿-化动力-免疫”治疗胶质瘤的研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[492,"LncRNA GAS5通过YAP靶向调控肿瘤相关巨噬细胞极化促进子宫内膜癌发展的研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[493,"E3泛素连接酶HECTD3通过调控肿瘤相关巨噬细胞抑制乳腺癌生长的功能机制研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[494,"m6A甲基化通过Integrinβ1信号通路调节软骨内成骨分化中间充质干细胞聚集的研究","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[495,"新型CRISPR/Cas12a纳米酶生物传感器的构建及其在即时检测中的应用","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[496,"成人型早衰患者WRN突变修复后通过调控miR-29b-TET1轴抑制间充质干细胞衰老","深圳市第二人民医院",{"v":20,"d":"20.00"}]
[497,"SNRPA调控linc01089外显子跳跃及其在肝细胞癌转移过程中的作用机制研究","深圳市第二人民医院",{"v":16,"d":"16.00"}]
[498,"剪切因子SMD1通过调控Bcl-X可变剪切抑制乳腺癌凋亡的机制研究","深圳市第二人民医院",{"v":16,"d":"16.00"}]
[499,"EphA2抑制剂ALW-II-41-27调控HMGB1-Nrf2-NF-κB/Akt信号通路改善氧化应激反应抑制急性胰腺炎的作用机制","深圳市第二人民医院",{"v":15,"d":"15.00"}]
[500,"基于肿瘤类器官模型探索上尿路上皮癌耐药的分子机制及精准用药策略","深圳市第二人民医院",{"v":15,"d":"15.00"}]
[501,"A/E大肠杆菌EspF蛋白通过氧化应激反应诱导宿主细胞DNA突变的分子机制","深圳市第二人民医院",{"v":15,"d":"15.00"}]
[502,"组织蛋白酶B调控Caspase-1介导的细胞焦亡在糖尿病心肌病中的机制研究","深圳市第二人民医院",{"v":14,"d":"14.00"}]
[503,"IL-1β激活TNF信号通路调控关节软骨细胞凋亡的数学建模与分析","深圳市第二人民医院",{"v":13,"d":"13.00"}]
[504,"压力微环境通过ROCK/Rho-GTP信号通路下调c-fos影响成纤维细胞纤维化功能的机制研究","深圳市第二人民医院",{"v":13,"d":"13.00"}]
[505,"复合细胞片层的仿生“分子胶水”修复全层皮肤缺损的研究","深圳市第二人民医院",{"v":13,"d":"13.00"}]
[506,"CD146作为髓系细胞检查点，促进肿瘤免疫逃逸机制的研究","深圳市第二人民医院",{"v":13,"d":"13.00"}]
[507,"AMPK调控内质网应激激酶PERK介导的神经元自噬在缺血脑卒中急性期的机制研究","深圳市第二人民医院",{"v":12,"d":"12.00"}]
[508,"β-防御素1激活精子CCR 6/CatSper1参与精子活力和功能的机制及其在男性生殖的应用探索","深圳市第二人民医院",{"v":10,"d":"10.00"}]
[509,"基于脑连接组学评估脑深部电刺激术精准治疗帕金森病手术靶点的研究","深圳市第二人民医院",{"v":10,"d":"10.00"}]
[510,"基于单细胞微流控芯片探索MCPIP1在三阴性乳腺癌转移中的作用机制","深圳市第二人民医院",{"v":10,"d":"10.00"}]
[511,"m6A修饰在神经病理性疼痛阿片药物依赖中的作用及机制","深圳市第三人民医院",{"v":30,"d":"30.00"}]
[512,"HPV E6/E7通过巨噬细胞促进头颈癌放疗敏感的新机制研究","深圳市第三人民医院",{"v":30,"d":"30.00"}]
[513,"褪黑素介导GSK3/IL-17A预防和治疗小鼠肺移植闭塞性细支气管炎的作用及机制研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[514,"Tim-1+调节性B细胞通过抑制中性粒细胞CXCR1/2的表达保护肝脏缺血再灌注损伤的机制研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[515,"二甲双胍通过抑制NLRP3炎症小体激活缓解NASH发生发展的实验研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[516,"非TNF靶向治疗类风湿关节炎合并潜伏性结核感染再激活的预防策略及生物标志物研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[517,"ZBTB48靶向MGAT5调控EMT抑制鼻咽癌侵袭转移的研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[518,"Rv2752c基因突变致结核分枝杆菌对利福平和异烟肼耐药的分子机制研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[519,"SARS-CoV-2多特异性基因工程抗体研发","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[520,"HIV-1感染者接种新型冠状病毒灭活疫苗的免疫效果及应答机制研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[521,"结核病人组织T细胞免疫学特征及调控巨噬细胞功能的机制研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[522,"深圳市MSM人群进行HIV-1暴露前预防推广及影响因素研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[523,"KatG和InhA突变基因在HIV合并结核分枝杆菌感染患者中流行特征及对临床抗结核分枝杆菌治疗疗效影响的研究","深圳市第三人民医院",{"v":20,"d":"20.00"}]
[524,"肿瘤多药耐药相关蛋白MRP3与抗肿瘤药物MTX的结合机制研究","深圳市第三人民医院",{"v":16,"d":"16.00"}]
[525,"外泌体microRNAs在ITGA8介导的NAFLD相关肝纤维化中的作用及机制研究","深圳市第三人民医院",{"v":13,"d":"13.00"}]
[526,"肺炎克雷伯菌多粘菌素作用靶点的筛选及功能研究","深圳市第三人民医院",{"v":10,"d":"10.00"}]
[527,"基于脆弱拟杆菌BF839辅助治疗儿童难治性癫痫临床试验的作用机制研究","深圳市儿童医院",{"v":30,"d":"30.00"}]
[528,"Wnt/β-catenin信号通路在雌激素诱导嗅上皮干细胞增殖与分化中的作用与机制","深圳市儿童医院",{"v":30,"d":"30.00"}]
[529,"DNA甲基化修饰调控CD4+T细胞亚群免疫重建的机制研究","深圳市儿童医院",{"v":30,"d":"30.00"}]
[530,"基于LncRNA HOTAIR/TCRP1/Akt/NF-κB轴调控慢性髓系白血病伊马替尼耐药的作用及机制研究","深圳市儿童医院",{"v":30,"d":"30.00"}]
[531,"基于脂质代谢通路的祛风蠲饮汤干预寒哮型儿童支气管哮喘的作用机制研究","深圳市儿童医院",{"v":30,"d":"30.00"}]
[532,"基于单细胞多组学研究儿童重度哮喘脱敏治疗前后气道黏膜免疫细胞的异质性及表观调控机制","深圳市儿童医院",{"v":20,"d":"20.00"}]
[533,"PLCG2新发突变位点P645L致病机制及其信号传导通路研究","深圳市儿童医院",{"v":20,"d":"20.00"}]
[534,"探索基于胆管β-淀粉样蛋白沉积新发现延缓胆道闭锁纤维化进程的研究","深圳市儿童医院",{"v":20,"d":"20.00"}]
[535,"邻苯二甲酸酯（PAEs）加速骨成熟相关机制的研究","深圳市儿童医院",{"v":20,"d":"20.00"}]
[536,"多学科过渡护理门诊对癫痫青少年从儿童到成人过渡的作用研究","深圳市儿童医院",{"v":20,"d":"20.00"}]
[537,"重型β地中海贫血患儿血浆特异性circRNA的筛选验证及其调控机制的研究","深圳市儿童医院",{"v":20,"d":"20.00"}]
[538,"ACTH对West综合征治疗效果的血清标志物及机理──全扫描定量及靶向定量蛋白质组学分析研究","深圳市儿童医院",{"v":18,"d":"18.00"}]
[539,"WAS蛋白缺陷致P13K/AKT信号异常与细胞骨架重构代谢调控机制研究","深圳市儿童医院",{"v":15,"d":"15.00"}]
[540,"Rho/ROCK信号通路调控MYOCD介导气道平滑肌细胞增殖参与哮喘气道重塑的机制研究","深圳市儿童医院",{"v":13,"d":"13.00"}]
[541,"miR-1290通过TLR4途径在NEC发病中的机制","深圳市儿童医院",{"v":10,"d":"10.00"}]
[542,"基于ICF-CY的个案管理康复模式对脑瘫儿童生存质量的影响","深圳市儿童医院",{"v":7,"d":"7.00"}]
[543,"LncRNA作为新分子标志物在镉致糖尿病中的功能及机制研究","深圳市福田区第二人民医院",{"v":59,"d":"59.00"}]
[544,"胸腺髓质成纤维细胞在类风湿关节炎免疫耐受紊乱中作用机制研究","深圳市福田区风湿病专科医院",{"v":10,"d":"10.00"}]
[545,"CD74/MIF信号通路在新型BPD细胞发育停滞中的分子机制研究","深圳市福田区妇幼保健院",{"v":20,"d":"20.00"}]
[546,"长链非编码RNA调控Hippo信号通路在补肾法促进卵巢生殖干细胞增殖和分化中的作用机制","深圳市福田区妇幼保健院",{"v":20,"d":"20.00"}]
[547,"APV疫苗后时代深圳市人群百日咳发病率估计研究","深圳市福田区疾病预防控制中心",{"v":20,"d":"20.00"}]
[548,"深圳地区麻风杆菌分子流行病学研究","深圳市福田区慢性病防治院",{"v":16,"d":"16.00"}]
[549,"数据和知识驱动的胎儿超声视频流脑皮质发育畸形智能诊断","深圳市妇幼保健院",{"v":30,"d":"30.00"}]
[550,"安子调冲汤经Foxp3/T-bet/GATA3信号通路调节母胎免疫耐受治疗抗磷脂综合征复发性流产的研究","深圳市妇幼保健院",{"v":24,"d":"24.00"}]
[551,"基于出生队列的孕期低浓度PM2.5暴露及成分对早产的影响及LINE甲基化机制的研究","深圳市妇幼保健院",{"v":21,"d":"21.00"}]
[552,"布洛芬通过调控血管生成参与支气管肺发育不良的作用机制","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[553,"高氧暴露对早产儿子宫腺体发育的影响及作用机制研究","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[554,"家族聚集性Turner综合征致病基因的研究","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[555,"外泌体miR-4454靶向调控CYLD介导的血管生成新机制在子宫内膜异位症发生发展中的实验研究","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[556,"聚乙二醇/聚乙烯亚胺/超声微泡介导Myc抑制PD-L1治疗卵巢癌干细胞的研究","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[557,"补肾活血法诱导母胎免疫耐受治疗复发性流产合并抗磷脂抗体综合征的机制研究","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[558,"基于Rictor/mTORC2信号通路研究针刺调控肠道菌群对早发性卵巢功能不全小鼠卵巢颗粒细胞抑制凋亡的机制研究","深圳市妇幼保健院",{"v":20,"d":"20.00"}]
[559,"多功能磁性微纳生物材料靶向结合及递送精子的研究","深圳市妇幼保健院",{"v":17,"d":"17.00"}]
[560,"基于真实世界数据的围产期抑郁筛查与干预体系研究","深圳市妇幼保健院",{"v":15,"d":"15.00"}]
[561,"G-CSF上调HOXA10表达提高反复种植失败患者子宫内膜容受性的机制研究","深圳市妇幼保健院",{"v":13,"d":"13.00"}]
[562,"基于注视点相关电位在孤独症谱系障碍高危儿局限兴趣的早期预测性研究","深圳市妇幼保健院",{"v":11,"d":"11.00"}]
[563,"基于深圳市出生队列祖辈-父辈共同养育关系模型的探索及验证","深圳市妇幼保健院",{"v":10,"d":"10.00"}]
[564,"基于IMB模型的妊娠期糖尿病孕妇群组保健体系的构建","深圳市妇幼保健院",{"v":6,"d":"6.00"}]
[565,"PTEN通路在牛磺酸改善小鼠自闭症行为的作用研究","深圳市光明区妇幼保健院",{"v":10,"d":"10.00"}]
[566,"铁皮石斛多糖对动脉粥样硬化大鼠的EPCs的数量和功能的影响研究","深圳市光明区妇幼保健院",{"v":10,"d":"10.00"}]
[567,"石墨烯量子点在卫生检验检测中的应用与研究","深圳市光明区疾病预防控制中心（深圳市光明区检验中心）",{"v":10,"d":"10.00"}]
[568,"核设施烟羽应急计划区内典型建筑物隐蔽效果及其对防护行动影响研究","深圳市环境监测中心站",{"v":40,"d":"40.00"}]
[569,"深圳市典型饮用水水源地水体中微塑料的组成分布特征与差异性分析","深圳市环境科学研究院",{"v":40,"d":"40.00"}]
[570,"深圳社区健康人群中可移动替加环素耐药基因的流行病学研究","深圳市疾病预防控制中心",{"v":30,"d":"30.00"}]
[571,"深圳市空气质量健康指数和臭氧诱导心血管损伤及易感性分析在人群队列中的应用研究","深圳市疾病预防控制中心",{"v":30,"d":"30.00"}]
[572,"重要媒传血液原虫全集成碟式微流控基因芯片检测方法的研发及应用","深圳市疾病预防控制中心",{"v":20,"d":"20.00"}]
[573,"医院污水中耐药基因与抗菌药物的污染特征及精准消毒研究","深圳市疾病预防控制中心",{"v":20,"d":"20.00"}]
[574,"多溴二苯醚暴露对甲状腺乳头状癌发病及代谢组的影响研究","深圳市疾病预防控制中心",{"v":20,"d":"20.00"}]
[575,"基于芳香烃受体作用的有机污染物内暴露与甲状腺疾病的关联研究","深圳市疾病预防控制中心",{"v":18,"d":"18.00"}]
[576,"六价铬致肺癌中线粒体DNA损伤诱导线粒体自噬的作用机制研究","深圳市疾病预防控制中心",{"v":15,"d":"15.00"}]
[577,"肽半抗原结构与抗体特异性构效规律及酪蛋白单氨基酸突变位点抗体制备方法研究","深圳市计量质量检测研究院",{"v":40,"d":"40.00"}]
[578,"小分子夹心免疫复合物形成的结构基础及构效关系研究","深圳市计量质量检测研究院",{"v":30,"d":"30.00"}]
[579,"双抗体介导的差向异构体精准识别基础及比率免疫传感方法研究","深圳市计量质量检测研究院",{"v":30,"d":"30.00"}]
[580,"基于磁共振数据分析小脑后叶功能探索经颅直流电刺激(tDCS)治疗精神分裂症的神经作用机制","深圳市康宁医院",{"v":20,"d":"20.00"}]
[581,"额极的经颅直流电刺激改善老年人风险决策能力的研究","深圳市康宁医院",{"v":14,"d":"14.00"}]
[582,"DLX3/SAHH/EZH2轴介导的组蛋白H3K27三甲基化在牙槽骨改建中的作用机制研究","深圳市口腔医院",{"v":20,"d":"20.00"}]
[583,"深圳极危物种紫纹兜兰野外种群重建土壤微生物组与代谢组响应机制研究","深圳市兰科植物保护研究中心",{"v":60,"d":"60.00"}]
[584,"CRISPR-Act2.0转录激活铁皮石斛多个内源基因提高石斛碱产量的研究","深圳市兰科植物保护研究中心",{"v":40,"d":"40.00"}]
[585,"rTMS联合踝关节智能康复机器人双向促通训练模式对卒中患者脑神经重塑作用机理研究","深圳市老年医学研究所",{"v":28,"d":"28.00"}]
[586,"基于IR/PI3K-Akt/NF-κB信号互作系统探讨天泰1号对阿尔茨海默病与2型糖尿病异病同治的分子机制","深圳市老年医学研究所",{"v":20,"d":"20.00"}]
[587,"3-取代吲哚酮类化合物：增强MEF2转录活性防治阿尔茨海默症之分子机理研究","深圳市老年医学研究所",{"v":20,"d":"20.00"}]
[588,"柴胡-白芍药对通过菌群-肠-脑轴调节5-HT-Glu/GABA长反馈神经环路抗抑郁的新机制研究","深圳市老年医学研究所",{"v":20,"d":"20.00"}]
[589,"白藜芦醇通过ERα- SIRT1/PGC -1α新通路抑制内皮细胞损伤延缓衰老的研究","深圳市龙岗区第二人民医院",{"v":19,"d":"19.00"}]
[590,"SIRT1-SOD2对TBI后神经元线粒体损伤的调节机制","深圳市龙岗区第三人民医院",{"v":20,"d":"20.00"}]
[591,"LncRNA GATA3-AS1通过双途径调控GATA3激活JAK-STAT通路在变应性鼻炎Th2免疫反应中的机制研究","深圳市龙岗区耳鼻咽喉医院",{"v":30,"d":"30.00"}]
[592,"多功能影像导航纳米系统在鼻咽癌协同放化疗中的应用研究","深圳市龙岗区耳鼻咽喉医院",{"v":30,"d":"30.00"}]
[593,"结合大数据分析Bcl2调控神经重构与年龄相关性耳聋的机制研究","深圳市龙岗区耳鼻咽喉医院",{"v":24,"d":"24.00"}]
[594,"生物力学因素在鼻咽癌恶性进展中的作用及机制研究","深圳市龙岗区耳鼻咽喉医院",{"v":20,"d":"20.00"}]
[595,"龙胆口山酮酚抑制Sirt1去乙酰化RORγt调控Th17细胞分化治疗过敏性哮喘的机制研究","深圳市龙岗区耳鼻咽喉医院",{"v":20,"d":"20.00"}]
[596,"HPV E6通过外泌体miR-106a~363簇影响宫颈微环境巨噬细胞极化的机制研究","深圳市龙岗区妇幼保健院",{"v":10,"d":"10.00"}]
[597,"以家庭为中心的出院准备计划在低出生体重儿中的应用研究","深圳市龙岗区妇幼保健院",{"v":1,"d":"1.00"}]
[598,"脊柱全内镜下腰椎间盘髓核摘除术后应用甲基强的松龙的临床疗效及并发症研究","深圳市龙岗区骨科医院",{"v":6,"d":"6.00"}]
[599,"噪声聋易感性基因拷贝数的变异研究","深圳市龙岗区疾病预防控制中心",{"v":10,"d":"10.00"}]
[600,"心脏肌成纤维细胞通过间隙连接蛋白Cx43抑制干细胞成心肌分化的分子机制研究","深圳市龙岗区人民医院",{"v":20,"d":"20.00"}]
[601,"转录因子HOXA6调控miR-3618/1306基因簇/AQP1信号轴促进胃癌上皮间质转化的研究","深圳市龙岗区人民医院",{"v":15,"d":"15.00"}]
[602,"640层CT骨三维成像联合3D打印Chiari畸形模型的临床价值研究","深圳市龙岗中心医院",{"v":15,"d":"15.00"}]
[603,"温针干预对腰椎术后综合征腰椎磁共振T2弛豫时间的影响及机制研究","深圳市龙岗中心医院",{"v":13,"d":"13.00"}]
[604,"孕期被动吸烟引起儿童注意缺陷多动障碍的表观遗传机制研究","深圳市龙华区妇幼保健院",{"v":30,"d":"30.00"}]
[605,"肠道菌群及其代谢物对围产期抑郁风险轨迹预测的作用和机制研究","深圳市龙华区妇幼保健院",{"v":20,"d":"20.00"}]
[606,"深圳地区PM2.5中新型污染物检测识别及暴露风险评价的关键技术研究","深圳市龙华区疾病预防控制中心",{"v":7,"d":"7.00"}]
[607,"深圳市龙华区10岁以下社区儿童肺炎链球菌携带、耐药菌株及疾病负担研究","深圳市龙华区慢性病防治中心（精神卫生中心）",{"v":10,"d":"10.00"}]
[608,"核受体共激活因子NCOA6靶向Ascl2调控侵润型滋养层细胞分化的分子机制研究","深圳市龙华区人民医院",{"v":20,"d":"20.00"}]
[609,"铁过载调控骨细胞凋亡及RANKL分泌在绝经后骨质疏松发生中的作用及机制","深圳市龙华区人民医院",{"v":20,"d":"20.00"}]
[610,"肾癌基因表达谱分析及NFIA/PDHB/FOXO3信号轴在肾癌细胞侵袭转移中的作用及调控机制","深圳市龙华区人民医院",{"v":20,"d":"20.00"}]
[611,"核受体HNF4α调控前列腺癌干细胞干性维持的分子机制","深圳市龙华区人民医院",{"v":20,"d":"20.00"}]
[612,"脂肽iturin A作为肝癌免疫治疗佐剂的效果与机制","深圳市龙华区人民医院",{"v":19,"d":"19.00"}]
[613,"去泛素化酶USP24通过TTC36调控酪氨酸代谢关键酶HPD的分子机制研究","深圳市龙华区人民医院",{"v":16,"d":"16.00"}]
[614,"基于运动想象的脑机接口训练对于缺血性脑卒中上肢功能康复的疗效观察及机制研究","深圳市龙华区中心医院",{"v":30,"d":"30.00"}]
[615,"骨髓增殖性肿瘤外泌体上调骨髓源性EPC中VEGFR信号通路促进疾病进展的机制研究","深圳市龙华区中心医院",{"v":20,"d":"20.00"}]
[616,"生物分子响应型水凝胶用于干细胞微组织构建及颌骨组织修复研究","深圳市龙华区中心医院",{"v":20,"d":"20.00"}]
[617,"METTL7B通过上调EGR1表达抑制肾癌增殖的分子机制研究","深圳市龙华区中心医院",{"v":20,"d":"20.00"}]
[618,"双输入分布式参数模型定量检测肝微循环机制及肿瘤分级研究","深圳市龙华区中心医院",{"v":20,"d":"20.00"}]
[619,"基于ANT-AMPK-mTORC1信号通路研究苍术苷激活自噬促使脂肪肝细胞脂质降解的机制","深圳市龙华区中心医院",{"v":20,"d":"20.00"}]
[620,"基于城市生活污水监测的传染病早期预警体系建设（以诺如病毒为示范探索病原体）","深圳市罗湖区疾病预防控制中心",{"v":13,"d":"13.00"}]
[621,"环境污染物多环芳烃对哮喘候选基因chr.17q12-21区域影响及机制研究","深圳市罗湖医院集团",{"v":30,"d":"30.00"}]
[622,"转录子ISX-Brd4对肺癌转移及微环境的调控作用与机制研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[623,"基于人工智能深度学习的影响产后盆底功能障碍产科因素的前瞻性研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[624,"CX43/GJIC与Ca2+/CaM交互作用平衡骨代谢偶联抗骨质疏松的机制研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[625,"HSP27磷酸化对中暑损伤的肠上皮紧密连接的作用及机制研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[626,"FRS2基因扩增激活FGF通路促进膀胱癌进展的分子机制及其作为厄达替尼靶向用药标志物的研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[627,"基于云平台的老年人整合照护模式构建与评价","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[628,"热灸膏穴位贴敷激活“皮–脑轴”治疗免疫相关皮肤病效应及其机制研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[629,"基于清肺排毒汤双向调节免疫系统治疗新型冠状病毒肺炎的机制研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[630,"结肠菌群介导鞣花酸生物转化Urolithins及其关联体的分子机制研究","深圳市罗湖医院集团",{"v":20,"d":"20.00"}]
[631,"包载表柔比星的自驱动变形多肽纳米粒用于膀胱癌治疗的研究","深圳市罗湖医院集团",{"v":17,"d":"17.00"}]
[632,"构建人FGFR3表达重组酵母疫苗诱导DC-CTL细胞特异性杀伤膀胱癌细胞的研究","深圳市罗湖医院集团",{"v":15,"d":"15.00"}]
[633,"基于基层医疗机构的高血压智能化辅助决策系统的验证和应用研究","深圳市慢性病防治中心",{"v":12,"d":"12.00"}]
[634,"基于SIP/S1Pr1信号通路探讨SEW2871对孤独症社交行为的影响及作用机制","深圳市南山区妇幼保健院",{"v":20,"d":"20.00"}]
[635,"孕早中期脂肪分布变化对妊娠期糖尿病的影响及相关机制研究","深圳市南山区妇幼保健院",{"v":13,"d":"13.00"}]
[636,"室内灰尘中杀虫剂残留时空变化及人群健康风险评估","深圳市南山区疾病预防控制中心",{"v":18,"d":"18.00"}]
[637,"叶酸调控同型半胱氨酸代谢关键酶基因甲基化和羟甲基化对缺血性脑卒中的作用机制研究","深圳市南山区慢性病防治院",{"v":10,"d":"10.00"}]
[638,"HIV/梅毒自检二次传递仿真模型在识别MSM人群关键人物的应用研究","深圳市南山区慢性病防治院",{"v":10,"d":"10.00"}]
[639,"血清外泌体环状RNAs对糖尿病视网膜病变的调控作用研究","深圳市南山区蛇口人民医院",{"v":13,"d":"13.00"}]
[640,"面向基层群体规模化乳腺癌筛查的系统关键技术研究及临床验证","深圳市南山区医疗集团总部",{"v":10,"d":"10.00"}]
[641,"双酚A及其主要替代物的生殖毒性及毒理机制","深圳市农产品质量安全检验检测中心",{"v":40,"d":"40.00"}]
[642,"本地优势天敌叉角厉蝽对重大入侵农业害虫草地贪夜蛾的控制作用基础研究","深圳市农业科技促进中心",{"v":60,"d":"60.00"}]
[643,"基于微透析和代谢组学探讨“麻黄-桂枝药对”对慢性脑缺血大鼠的神经保护作用","深圳市坪山区妇幼保健院",{"v":20,"d":"20.00"}]
[644,"基于机器学习识别社区环境特征与重大慢性病发生风险的关联性及潜在机制研究","深圳市坪山区疾病预防控制中心",{"v":7,"d":"7.00"}]
[645,"基于影像基因组学数据的结直肠癌智能诊断研究","深圳市坪山区人民医院",{"v":20,"d":"20.00"}]
[646,"DNA甲基化修饰调控肾结石形成的机制研究","深圳市坪山区人民医院",{"v":19,"d":"19.00"}]
[647,"TRPC5/NLRP3通过上调气道上皮HMGB1表达介导哮喘气道炎症的机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[648,"气道流感嗜血杆菌定植通过激活BAFF/IL-17介导慢阻肺气道炎症的机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[649,"巨噬细胞ADK对心肌梗死后心室重塑的影响及其分子机制","深圳市人民医院",{"v":30,"d":"30.00"}]
[650,"时序性抗菌-促再生的生物可降解三维打印聚氨酯骨修复支架及其作用机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[651,"FtMt在3D培养骨髓间充质干细胞定向诱导分化为神经元细胞中的作用和蛋白组学分析","深圳市人民医院",{"v":30,"d":"30.00"}]
[652,"基于Hi-C方法确定SLE-iPSC向树突状细胞分化相关增强子调控网络及机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[653,"酪氨酸激酶受体抑制剂调控肿瘤PD-L1在黑素瘤免疫治疗中的作用与机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[654,"新型聚多巴胺纳米包裹VEGF-siRNA靶向RPE细胞治疗脉络膜新生血管性眼病的实验研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[655,"内耳导入外源性Klotho基因防治老年性耳聋的实验研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[656,"胶原-纳米金材料的构建及其激光辅助修复皮肤创面机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[657,"基于黑磷纳米材料靶向线粒体低温光热/光动力/气体协同治疗肿瘤及其机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[658,"Ras突变结直肠癌中MEK抑制剂抗性逆转因子的鉴定及其机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[659,"复合纳米给药系统用于鼻咽癌的放疗增敏及光控基因治疗","深圳市人民医院",{"v":30,"d":"30.00"}]
[660,"磁共振基于自旋锁定的大分子质子分数（MPF-SL）成像在精准量化肝纤维化细胞外基质的研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[661,"多粘菌素耐药菌及mcr基因在临床及相关水环境中的时空演变和扩散机制研究","深圳市人民医院",{"v":30,"d":"30.00"}]
[662,"基于对Tau蛋白的降解作用研究一种天然活性化合物的神经保护作用","深圳市人民医院",{"v":30,"d":"30.00"}]
[663,"CFB介导线粒体DNA氧化损伤参与糖尿病视网膜病变炎症调控的机制研究","深圳市人民医院",{"v":29,"d":"29.00"}]
[664,"吸附阻滞介导的碳青霉烯耐药肺炎克雷伯菌抗噬菌体机制研究","深圳市人民医院",{"v":26,"d":"26.00"}]
[665,"NOV/CCN3剪切异构体诱导胶质瘤化疗耐药的分子机制研究","深圳市人民医院",{"v":25,"d":"25.00"}]
[666,"三氧化二砷靶向BCL6抑制弥漫性大B细胞淋巴瘤的机制研究","深圳市人民医院",{"v":22,"d":"22.00"}]
[667,"MALT1在微塑料诱导的哮喘气道炎症加重中的调节机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[668,"Casticin对吸烟诱导慢阻肺气道上皮细胞衰老的干预机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[669,"肠道菌群调控肠道屏障影响冠状动脉粥样硬化进展的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[670,"极低强度声动力治疗通过Nrf2/HO-1通路拯救巨噬细胞程序性坏死从而抑制动脉粥样硬化进展","深圳市人民医院",{"v":20,"d":"20.00"}]
[671,"重组rIL-22长双歧杆菌对克罗恩病肠干细胞死亡免疫机制的研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[672,"胆汁酸诱导肝星状细胞焦亡促进肝纤维化的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[673,"新型环状RNA circ-ECH1靶向miR-132-3p调控细胞自噬及其在BPD发生的分子机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[674,"从PI3K-Akt通路探讨1型黏蛋白在新生儿坏死性小肠结肠炎肠黏膜细胞凋亡调控中的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[675,"袋鼠式护理通过脑-肠-微生物轴调控5-HT信号通路降低早产儿喂养不耐受发生率的分子机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[676,"基于NOX/ROS信号探讨黄连素阻断ANCA对肾小球血管内皮细胞损伤作用及机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[677,"基于空间转录组解析IgA肾病患者免疫细胞转化及基因调控机制","深圳市人民医院",{"v":20,"d":"20.00"}]
[678,"MSCs来源外泌体复合亲和水凝胶修复软骨缺损的机制和应用研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[679,"M1型巨噬细胞来源外泌体通过lncRNAs抑制间充质干细胞成骨分化加重II型糖尿病种植体周围炎的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[680,"GSK-3在炎症牙髓-牙本质修复性再生中的作用及机制的体外研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[681,"MALAT1调控NAIPs转录影响NLRC4炎性小体活化在铜绿假单胞菌致急性肺损伤中的作用及机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[682,"NIK/NF-κB2信号通路在cIAPs抑制剂Birinapant所诱导的头颈部鳞癌免疫原性细胞死亡中的作用和机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[683,"GRP78纳米抗体CAR-NK细胞的构建及抗肿瘤研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[684,"靶向HPV E6/E7的TCR-T细胞治疗HPV（+）子宫颈癌的研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[685,"METTL7B通过m6A甲基化修饰COL11A1调控肺腺癌肿瘤微环境的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[686,"调控肿瘤微环境的智能型纳米药物抑制肝癌微波消融后复发进展的研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[687,"外泌体源性lncRNA-SNHG7通过miR-216b-5p/HK2通路调控肝癌糖代谢重编程的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[688,"Linc00483结合HuR蛋白促进Drp1表达导致线粒体分裂/融合失衡诱导胃癌细胞5-Fu耐药","深圳市人民医院",{"v":20,"d":"20.00"}]
[689,"INFβ通过ISG15/B7H4调控结直肠癌微环境中CTL细胞及其作用机制","深圳市人民医院",{"v":20,"d":"20.00"}]
[690,"基于循证指南5A理论指引下护士职业性腰背痛的实验性研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[691,"细胞片-胶原基皮肤再生支架的制备及其糖尿病皮肤溃疡修复机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[692,"异质结功能化酵母细胞介导肿瘤催化与免疫协同治疗研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[693,"外泌体联合壳聚糖水凝胶调控巨噬细胞极化治疗急性心肌梗死的研究及分子影像评价","深圳市人民医院",{"v":20,"d":"20.00"}]
[694,"载RSL3磁性靶向微泡介导M2型巨噬细胞铁死亡治疗三阴性乳腺癌的机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[695,"肝脏肿瘤消融治疗的增强现实导航系统的关键技术研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[696,"性早熟特异性肠道菌群发现及肠道微生态干预研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[697,"管花苷B通过靶向KDM3A抑制Hippo下游基因增强子活性在肝癌侵袭转移中的作用及机制研究","深圳市人民医院",{"v":20,"d":"20.00"}]
[698,"miR-142-3p调控HMGB1-TLR通路抑制感染后肠易激综合征发生的作用机制研究","深圳市人民医院",{"v":15,"d":"15.00"}]
[699,"机械敏感阳离子信号通路Piezo1通过钙稳态调控小梁网细胞线粒体功能的机制研究","深圳市人民医院",{"v":12,"d":"12.00"}]
[700,"基于小胶质细胞的胶质瘤生物治疗的研究","深圳市瑞普逊干细胞再生医学研究院",{"v":60,"d":"60.00"}]
[701,"DRP1介导的线粒体自噬在肺动脉高压发生发展过程中的作用及其机制研究","深圳市瑞普逊干细胞再生医学研究院",{"v":40,"d":"40.00"}]
[702,"短链脂肪酸代谢酶编码基因ECHS1突变致Leigh综合征的分子机制研究","深圳市卫生健康发展研究中心",{"v":13,"d":"13.00"}]
[703,"VSIG4调控小胶质/巨噬细胞表型转换对脑出血 炎症损伤的作用及机制研究","深圳市盐田区人民医院",{"v":20,"d":"20.00"}]
[704,"基于DCE-MRI的瘤内和瘤周影像组学预测乳腺癌腋窝淋巴结转移研究","深圳市盐田区人民医院",{"v":20,"d":"20.00"}]
[705,"α2A肾上腺素能受体在阿托品抑制小鼠形觉剥夺性近视中的作用及机制","深圳市眼科医院",{"v":22,"d":"22.00"}]
[706,"基因编辑RhoA在MYOC相关青光眼模型中的应用及分子机制研究","深圳市眼科医院",{"v":20,"d":"20.00"}]
[707,"基于条件重编程人泪腺成体干细胞的泪腺功能重建的研究","深圳市眼科医院",{"v":15,"d":"15.00"}]
[708,"深圳市青少年视网膜周边屈光数据库及近视智能防控系统的构建","深圳市眼科医院",{"v":15,"d":"15.00"}]
[709,"基于整合“化学指纹图谱-活性荧光指纹图谱”策略的中药药效物质快速辨识的方法学研究","深圳市药品检验研究院（深圳市医疗器械检测中心）",{"v":50,"d":"50.00"}]
[710,"基于AI的乳腺癌智能检测系统关键技术研究","深圳市医学信息中心",{"v":20,"d":"20.00"}]
[711,"硫酸铟对活性氧自由基及肠道干细胞增殖分化的影响","深圳市职业病防治院",{"v":9,"d":"9.00"}]
[712,"尘肺患者心理弹性与综合肺康复效果的相关性研究及以心理干预为主导的护理策略构建","深圳市职业病防治院",{"v":5,"d":"5.00"}]
[713,"人脐带间充质干细胞治疗I/II型糖尿病大鼠勃起功能障碍的实验及临床前研究","深圳市中西医结合医院",{"v":15,"d":"15.00"}]
[714,"基于IRE1α/ XBP1通路研究紫花前胡素抗阿尔茨海默症的分子机制","深圳市中西医结合医院",{"v":15,"d":"15.00"}]
[715,"醒脑开窍针刺法通过TRIM2-CCDC53内体分选抗帕金森病痴呆铁死亡的机制探讨","深圳市中西医结合医院",{"v":12,"d":"12.00"}]
[716,"藏线缝合修补术治疗肛瘘的临床疗效研究","深圳市中医肛肠医院（福田）",{"v":3,"d":"3.00"}]
[717,"基于SIRT3调控成纤维细胞糖代谢重编程探讨益气活血法干预CKD肾小管间质纤维化的机制研究","深圳市中医院",{"v":20,"d":"20.00"}]
[718,"基于多模态MRI和机器学习探索抑郁症认知损害的肾虚证中枢响应模式","深圳市中医院",{"v":20,"d":"20.00"}]
[719,"“腰-盆-髋”曲率影响腰椎斜扳手法精准椎体节段定位的力学机制研究","深圳市中医院",{"v":20,"d":"20.00"}]
[720,"基于“扶正祛邪”理论探讨通脉地仙丸通过AMPK/ULK1调控线粒体自噬在改善慢性心衰心肌能量代谢重构的作用机制研究","深圳市中医院",{"v":20,"d":"20.00"}]
[721,"从“舌-小肠轴”探讨活血降糖饮对糖尿病前期大鼠脂肪偏好的影响","深圳市中医院",{"v":20,"d":"20.00"}]
[722,"基于HBx/PI3K/Akt通路探讨疏肝健脾养血方及槲皮素抗肝癌干细胞的机制","深圳市中医院",{"v":17,"d":"17.00"}]
[723,"GFM1基因突变在线粒体病发生中的作用及其突变谱的建立","深圳市中医院",{"v":15,"d":"15.00"}]
[724,"调任通督针法对卒中后抑郁海马神经元损伤的影响","深圳市中医院",{"v":15,"d":"15.00"}]
[725,"调曲正盆整脊法防治腰椎滑脱症的腰椎-骨盆生物力学机制研究","深圳市中医院",{"v":15,"d":"15.00"}]
[726,"基于椎间盘应力对Ruffini小体的影响探讨颈椎旋转手法治疗颈性眩晕的生物力学及本体感觉调节机制","深圳市中医院",{"v":15,"d":"15.00"}]
[727,"基于TLR/MyD88/NF-kB p65信号系统研究中药天竺雾化液对大鼠细菌性慢性咽炎的干预机制","深圳市中医院",{"v":15,"d":"15.00"}]
[728,"病炎清颗粒调控甘氨酸代谢介导NLRPS炎症小体信号通路治疗H1N1肺炎肺损伤的机制研究","深圳市中医院",{"v":15,"d":"15.00"}]
[729,"基于中缝背核-海马环路研究预电针防治APP/PS1小鼠学习记忆障碍的作用机制","深圳市中医院",{"v":14,"d":"14.00"}]
[730,"基于磷酸化AMPK探讨健脾化浊法改善肠道菌群失调对PCOS-IR的影响及机制研究","深圳市中医院",{"v":12,"d":"12.00"}]
[731,"从TRPML1介导的溶酶体活性探讨广藿香醇抗侵入细胞内幽门螺杆菌的机制","深圳市中医院",{"v":10,"d":"10.00"}]
[732,"融合肌电与肌肉形变信息的运动意图识别及其应用研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[733,"基于声学人工结构的双频超声换能器及其多尺度内窥成像研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[734,"创伤后应激障碍核心表征的皮层下通路机制","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[735,"蜘蛛黏胶仿生的潮湿表面粘附性材料研究及其作为创伤封闭剂的应用","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[736,"基于溶酶体靶向嵌合体的新型仿生纳米粒用于治疗Alzheimer病的研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[737,"基于注意力和记忆机制的植保无人机视觉目标跟踪方法研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[738,"基于微流控的癌细胞迁移表型自动分选系统关键技术研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[739,"基于多点偶联的高效酶电化学二氧化碳还原体系的构建与应用","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[740,"登陆粤港澳大湾区台风降雨时空分布特征及机理研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[741,"含镁骨修复材料调控骨免疫微环境对骨组织再生的影响及机制研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[742,"基于天然产物的新型PI3K/AKT/mTOR抑制剂筛选及其抗肿瘤耐药的机制研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[743,"实体瘤靶向的增效HSV溶瘤病毒开发研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[744,"基于表面肌电宏观与微观表征的多自由度协同连续运动意图解码方法与应用研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[745,"数字化光子纳米喷流技术检测蛋白标志物用于阿尔茨海默病早期诊断的研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[746,"一种用于超声造影超谐波成像的双频阵列超声换能器的技术研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[747,"基于代谢检查点免疫调控的纳米工程化CAR-T细胞抗肿瘤治疗研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[748,"基于光声光谱技术的光动力治疗精准评估和疗效优化","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[749,"全球疫情常态化下的深圳市新型冠状病毒肺炎传染病传播研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[750,"朝藿定C治疗骨关节炎的作用及机制研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[751,"表达透明质酸酶的新型NKG2D CAR-T细胞治疗胰腺癌的效果及机制研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[752,"大尺寸球栅阵列封装焊点缺陷激光超声非接触原位检测关键技术研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[753,"基于软组织损伤预测的机器人辅助经鼻采样手术入路规划与控制方法研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[754,"基于中观尺度脑功能成像技术的触觉工作记忆脑机制与阿尔茨海默病超早期预警","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[755,"超稳定纳米金刚石负载金属单原子催化剂在燃料电池中的应用","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[756,"酶催化的不对称光诱导自由基反应及其在多环天然产物合成中应用","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[757,"固态钠基双离子电池的梯度电解质多尺度设计及性能研究","深圳先进技术研究院",{"v":60,"d":"60.00"}]
[758,"基于国产加速器的3D弹性波场非迭代线性反演","深圳先进技术研究院",{"v":59.6,"d":"59.60"}]
[759,"高糖缓解焦虑的神经环路机制研究","深圳先进技术研究院",{"v":59,"d":"59.00"}]
[760,"Metabolitin-GPRC6A通路调控小肠GLP-1分泌在脂质代谢中的分子机制研究","深圳先进技术研究院",{"v":50,"d":"50.00"}]
[761,"心房颤动下血压变异机制及无创测量方法研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[762,"基于国密算法的车联网密码芯片安全性技术研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[763,"中值滤波取证及其图像篡改检测技术研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[764,"面向大规模数据的聚类优化技术研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[765,"基于神经肌肉多模生理信息的颈肩腰背痛智能诊断方法研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[766,"AAV逆向示踪病毒在食蟹猴运动神经环路解析中的应用","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[767,"干细胞来源外泌体的骨靶向修饰和miRNA药物递送治疗骨质疏松","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[768,"ERRa调控乳酸代谢影响肝脏糖异生通路的机制研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[769,"AMPK正调控NK细胞功能改善肿瘤免疫检查点治疗疗效的机制研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[770,"基于巨噬细胞替换和分型技术的衰老促AMD发病机制研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[771,"多模态内窥成像方法在体定量评估子宫内膜容受性的研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[772,"左氧氟沙星对小鼠缺血性脑卒中后血脑屏障损伤和神经炎症的治疗效果和药理机制研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[773,"基于知识与认知协同的水下机器人自主学习方法研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[774,"神经粘附蛋白修饰柔性微电极阵列用于无线供电便携式ECoG高性能神经接口","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[775,"机器人辅助可编程电子信息材料数字制造","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[776,"基于气液界面表面增强拉曼分析体系检测胰腺癌外泌体miRNA的研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[777,"分子尺度下LSPR热点在金属-半导体界面上的可视化研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[778,"各向异性电磁屏蔽导热一体化材料的制备、结构调控及其对力-热-电磁影响机制研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[779,"固态双离子电池设计及界面改性研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[780,"具有自修复性能的低表面能抗菌涂层构建及其海洋微生物腐蚀性能研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[781,"钙钛矿光伏材料离子迁移与界面缺陷的跨尺度研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[782,"基于超音速微粒轰击技术的表面纳米化海洋工程用钢的微生物腐蚀行为研究","深圳先进技术研究院",{"v":40,"d":"40.00"}]
[783,"可验证量子云计算关键技术研究","深圳职业技术学院",{"v":40,"d":"40.00"}]
[784,"高功率密度，高可靠性无电解电容电动汽车驱动系统研究","深圳职业技术学院",{"v":40,"d":"40.00"}]
[785,"高雄激素通过调节丙酮酸脱氢酶激酶4的表达抑制PCOS子宫内膜蜕膜化的机制研究","深圳中山泌尿外科医院",{"v":25,"d":"25.00"}]
[786,"piR-32678参与精子发生调控的分子机制研究","深圳中山泌尿外科医院",{"v":20,"d":"20.00"}]
[787,"卵巢子宫内膜异位症卵泡液巨噬细胞极化参与调控卵子质量的机制研究","深圳中山泌尿外科医院",{"v":15,"d":"15.00"}]
[788,"面向城市大型建筑物的六分量北斗实时变形监测设备","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[789,"车辆智能网联系统的安全机制研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[790,"针对微应力传感特性的应力发光和压电效应的耦合机理研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[791,"动物毒素多肽的致痒新型毒理作用与机制及相关抗瘙痒研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[792,"面向精准诊疗的激活型光热试剂开发","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[793,"寨卡病毒感染对子代脑损伤的多模态成像和药物干预研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[794,"肿瘤微环境重塑调节乳腺癌耐药性的产生及分子调控机理研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[795,"智能粘附材料的仿生梯度设计及高强耐久协同改性研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[796,"β,β-二氟烯醇硅醚的催化不对称构建及其在含氟手性酮合成中的应用","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[797,"高效钙钛矿三基色发光材料与显示器件","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[798,"纳米孪晶铜-石墨烯复合材料结构调控与性能研究","武汉大学深圳研究院",{"v":60,"d":"60.00"}]
[799,"机场净空区入侵小目标监视方法研究","武汉大学深圳研究院",{"v":58,"d":"58.00"}]
[800,"n型磷掺杂金刚石薄膜缺陷形成机理及调控研究","武汉大学深圳研究院",{"v":40,"d":"40.00"}]
[801,"基于高速、高分辨光学成像的激光加工熔池在线监测技术研究","武汉大学深圳研究院",{"v":40,"d":"40.00"}]
[802,"数字图像中高容量可逆信息隐藏技术研究","武汉大学深圳研究院",{"v":40,"d":"40.00"}]
[803,"银基离子固体场发射聚焦离子束（FIB）研究","武汉大学深圳研究院",{"v":40,"d":"40.00"}]
[804,"逐层涂膜技术实现有机光伏电池的大面积制备","武汉大学深圳研究院",{"v":40,"d":"40.00"}]
[805,"介孔限域定向排列的金属纳米颗粒无酶葡萄糖传感器电极材料研究","武汉大学深圳研究院",{"v":40,"d":"40.00"}]
[806,"面向太阳能驱动分解海水制氢的分级结构二氧化钛光催化材料高性能设计","武汉理工大学深圳研究院",{"v":60,"d":"60.00"}]
[807,"全无机钙钛矿量子点太阳能电池的界面工程与性能优化研究","武汉理工大学深圳研究院",{"v":60,"d":"60.00"}]
[808,"面向高密度闪存物理特征的大容量固态盘可靠性和性能优化研究","武汉理工大学深圳研究院",{"v":40,"d":"40.00"}]
[809,"光-GR/葡萄糖-葡萄糖氧化酶体系降解水中苯的氯代有机污染物的机制研究","武汉理工大学深圳研究院",{"v":40,"d":"40.00"}]
[810,"基于瞬态导向策略的α-酮酸酯惰性碳氢键官能化反应及其应用于多样性构建药物分子","武汉理工大学深圳研究院",{"v":40,"d":"40.00"}]
[811,"面向泛电动车无感快充的多方博弈共赢智能导航策略研究","武汉理工大学深圳研究院",{"v":40,"d":"40.00"}]
[812,"大规模集成电路设计安全性评估技术","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[813,"分布孔径毫米波雷达高分辨成像技术","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[814,"长航时自主水下航行器惯性基组合导航关键技术研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[815,"基于微流控技术的乳腺癌骨转移靶向药物筛选方法研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[816,"铁代谢在PTH调控空间失重环境下骨形成中的作用机制","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[817,"构建缺氧响应型前药Pro-PROTAC用于“化学敲除”己糖激酶2及其抗乳腺癌骨转移研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[818,"多水下航行器动态对接控制技术研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[819,"海况未知环境下模型数据混合驱动的AUV智能运动控制方法研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[820,"基于沟槽抑制效应的超疏水表面气膜增稳与减阻优化研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[821,"内波作用下海洋平台的流体动力特性及运动响应机理研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[822,"面向微小型飞行器的介电弹性体离面谐振驱动机理研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[823,"基于光控荧光开关的双模态智能防伪材料研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[824,"高性能铁基纳米晶软磁材料设计与制备","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[825,"面向高效率长寿命及低成本钙钛矿太阳能电池应用的关键材料研发","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[826,"基于碱液水电解制氢的强耦合杂化材料的设计合成及应用研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[827,"高热流环境下变物性纳米流体微通道冷却机理及逆向优化设计研究","西北工业大学深圳研究院",{"v":60,"d":"60.00"}]
[828,"面向通信计算一体化智能云网络的资源管理关键技术研究","西北工业大学深圳研究院",{"v":40,"d":"40.00"}]
[829,"面向智能家居的深度自组织麦克风阵列关键技术研究","西北工业大学深圳研究院",{"v":40,"d":"40.00"}]
[830,"声学超材料波动机制研究及承载一体化智能设计","西北工业大学深圳研究院",{"v":40,"d":"40.00"}]
[831,"活细胞内RNA动态正交双色成像研究","西北工业大学深圳研究院",{"v":40,"d":"40.00"}]
[832,"太赫兹波调制用金属/石墨烯异质微结构均匀微滴3D打印基础研究","西北工业大学深圳研究院",{"v":40,"d":"40.00"}]
[833,"应用透射电子在原子尺度上测量材料轨道各向异性","香港城市大学深圳福田研究院",{"v":60,"d":"60.00"}]
[834,"lncRNA DANCR调控间充质干细胞衰老的机制研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[835,"FAM129B信号通路在内体运输和肿瘤转移中的功能和机制研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[836,"肝癌肿瘤微环境的免疫逃逸机制的研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[837,"二维硫族化物的插层剥离制备、纳米复合及其电化学析氢研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[838,"基于半直驱同步磁阻电机的低成本穿戴式机械臂执行器设计与研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[839,"磁控超滑表面用于微液滴的定向快速收集和病原检测","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[840,"基于光电极改性的复合微生物-太阳能双电池系统对提升餐余废物处理效率研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[841,"沸石分子筛选择性吸附去除低温低浓度二氧化氮的研究","香港城市大学深圳研究院",{"v":60,"d":"60.00"}]
[842,"纳米金属颗粒的细胞吸收、溶解、分布及转化行为研究","香港城市大学深圳研究院",{"v":40,"d":"40.00"}]
[843,"多酚抑制丁香假单胞菌毒力的分子机理和应用研究","香港城市大学深圳研究院",{"v":40,"d":"40.00"}]
[844,"基于微流控磁粒子的前列腺癌视觉量化检测微芯片的研究","香港城市大学深圳研究院",{"v":40,"d":"40.00"}]
[845,"研发将单分子测序运用于癌症体细胞变异检测的实验方案与算法","香港大学深圳研究院",{"v":60,"d":"60.00"}]
[846,"联用宏基因组大数据挖掘与合成生物学策略挖掘海洋古菌活性天然产物","香港大学深圳研究院",{"v":60,"d":"60.00"}]
[847,"血管内皮细胞调控牙髓干细胞向血管壁细胞分化的分子机制研究","香港大学深圳研究院",{"v":58,"d":"58.00"}]
[848,"全极化合成孔径雷达提高多云环境下城市不透水面监测精度","香港大学深圳研究院",{"v":40,"d":"40.00"}]
[849,"城市化对近海海洋酸化影响的研究：以深圳湾为例","香港大学深圳研究院",{"v":40,"d":"40.00"}]
[850,"基于贝叶斯机器学习的海上风场偏航尾流控制分析","香港大学深圳研究院",{"v":40,"d":"40.00"}]
[851,"连续位错动力学的新模拟器","香港大学深圳研究院",{"v":40,"d":"40.00"}]
[852,"基于激光诱导协助纳米材料制备技术生产低成本高效活性催化剂的研究","香港大学深圳研究院",{"v":40,"d":"40.00"}]
[853,"ISM1 在肾脏发育与先天性肾缺如中的作用及其机制研究","香港大学深圳医院",{"v":30,"d":"30.00"}]
[854,"干燥综合征发病中γδT 细胞的致病作用及机制研究","香港大学深圳医院",{"v":30,"d":"30.00"}]
[855,"中心通路调控分生孢子发育在孢子丝菌致病性形成中的作用及机制研究","香港大学深圳医院",{"v":30,"d":"30.00"}]
[856,"研究钙信号调控因子CAMK1D对肝癌耐药性的作用和机制","香港大学深圳医院",{"v":30,"d":"30.00"}]
[857,"基于循环免疫细胞和免疫微环境的预后模型指导宫颈癌个体化治疗","香港大学深圳医院",{"v":30,"d":"30.00"}]
[858,"仿生膜纳米囊泡靶向治疗转移性肿瘤的疗效及机制研究","香港大学深圳医院",{"v":30,"d":"30.00"}]
[859,"脂联素adiponectin抑制NLRP3炎症小体介导的细胞焦亡在急性肾脏病中的保护机制及应用研究","香港大学深圳医院",{"v":28,"d":"28.00"}]
[860,"心肌细胞外泌体miR146a-5p通过调控巨噬细胞活化参与心肌梗死炎症反应","香港大学深圳医院",{"v":20,"d":"20.00"}]
[861,"母胎多源数据智能化集成管理","香港大学深圳医院",{"v":20,"d":"20.00"}]
[862,"家系模型探索非梗阻性无精子症新致病基因及双（多）基因致病机制分析","香港大学深圳医院",{"v":20,"d":"20.00"}]
[863,"P2X7受体可变剪切通过小胶质细胞极化平衡状态调控术后急性疼痛演化进程","香港大学深圳医院",{"v":20,"d":"20.00"}]
[864,"基于多能干细胞大脑类器官模型研究小胶质细胞在肾上腺脑白质营养不良中的作用和机制","香港大学深圳医院",{"v":20,"d":"20.00"}]
[865,"基于国际共识和人工智能实现鼻咽癌自动勾画和自动最优剂量学计划","香港大学深圳医院",{"v":20,"d":"20.00"}]
[866,"唇腭裂患儿一期唇腭鼻联合修复与传统分期修复的前瞻性随机对照研究","香港大学深圳医院",{"v":10,"d":"10.00"}]
[867,"基于LOGIT评定模型建立骨科住院患者跌倒综合评估及预防系统","香港大学深圳医院",{"v":8,"d":"8.00"}]
[868,"本征手性纳米颗粒诱导分子自发性对称性破缺","香港浸会大学深圳研究院",{"v":40,"d":"40.00"}]
[869,"靶向自噬过程抗神经退行性疾病的新型多肽药物研发","香港理工大学深圳研究院",{"v":60,"d":"60.00"}]
[870,"结合放射多组学与可解释模糊系统的鼻咽癌放疗预后预测","香港理工大学深圳研究院",{"v":60,"d":"60.00"}]
[871,"肝细胞特异性抑制MDM2反义寡核苷酸 (Antisense oligonucleotide) 药物用于治疗非酒精性脂肪性肝病的可行性研究","香港理工大学深圳研究院",{"v":60,"d":"60.00"}]
[872,"离子注入辅助超精密加工微结构光学元件亚表面损伤机理及抑制策略研究","香港理工大学深圳研究院",{"v":60,"d":"60.00"}]
[873,"基于富铜纳米团簇调控的超高强钢抗氢脆机理的原子尺度研究","香港理工大学深圳研究院",{"v":59,"d":"59.00"}]
[874,"基于自监督学习的大规模三维动态点云理解","香港理工大学深圳研究院",{"v":54,"d":"54.00"}]
[875,"基于扫频光源的高速大范围高精度测量技术研究","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[876,"基于第十族过渡金属硒化物异质结红外探测器制备与非制冷成像应用","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[877,"二维材料异质结中热载流子动力学的超快光谱研究","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[878,"关延迟反应的视网膜神经节细胞在聚焦/失焦图像检测中的作用：近视控制的新治疗靶点","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[879,"分子筛限域策略应用于CO2 加氢制多碳醇: 催化剂尺寸效应和反应机理探讨","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[880,"高强高韧梯度纳米结构轻质镁合金的超精密加工技术制备及其原子尺度结构演变和强化机理研究","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[881,"新型流式反应器设计与构筑及其电化学合成氨应用研究","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[882,"极端储运环境下锂离子电池火灾诱发机理与智慧探测研究","香港理工大学深圳研究院",{"v":40,"d":"40.00"}]
[883,"基于深度学习与大样本库的地球内部电导率结构成像方法研究","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[884,"基于无线电地图的低空无人机位置与路径最优化理论与算法研究","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[885,"面向中文医疗文本的基础自然语言理解方法研究","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[886,"面向B5G/6G的无人机通信理论和关键技术研究","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[887,"P4-ATPase酶对小分子催化转移过程的自由能势能面计算","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[888,"靶向雄激素代谢通路的抗前列腺疾病药物开发","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[889,"研究胰岛β细胞甜味受体的结构和治疗糖尿病的潜力","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[890,"锌离子抑制神经退行信号酶SARM1的分子机制","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[891,"注意偏向的认知加工机制及测量方法优化研究","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[892,"基于人工智能技术的新型无机手性材料的发现","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[893,"稠合环辛四芳烃类聚集诱导发光分子的设计、构效关系及应用研究","香港中文大学（深圳）",{"v":60,"d":"60.00"}]
[894,"基于区块链技术的数字孪生系统","香港中文大学（深圳）",{"v":40,"d":"40.00"}]
[895,"锁阳三萜类组分通过激活胆汁酸受体TGR5改善肥胖型II型糖尿病（T2DM）胰岛素分泌不足和胰岛素抵抗的分子机制研究","香港中文大学（深圳）",{"v":40,"d":"40.00"}]
[896,"高效窄带Eu2+掺杂的UCr4C4型红色氧化物荧光粉的结构设计和发光性能优化","中国地质大学深圳研究院",{"v":40,"d":"40.00"}]
[897,"胸腺增龄性萎缩中Wnt4调控胸腺上皮-间质转化（EMT）对胸腺上皮细胞（TEC）老化及逆转作用研究","中国科学院大学深圳医院（光明）",{"v":20,"d":"20.00"}]
[898,"CD36/Calpain-1/NLRP3轴调控的细胞焦亡途径及Th17/Treg炎症轴 探讨PCI术后再狭窄发生的内在机制","中国科学院大学深圳医院（光明）",{"v":17,"d":"17.00"}]
[899,"冷冻电镜与关联成像技术探究大脑突触传递的分子结构机理","中国科学院深圳理工大学(筹)",{"v":60,"d":"60.00"}]
[900,"用于揭示新环路形成的新型逆向跨单级示踪工具及应用","中国科学院深圳理工大学(筹)",{"v":60,"d":"60.00"}]
[901,"支架蛋白SHANK3量对突触可塑性调控之机制","中国科学院深圳理工大学(筹)",{"v":60,"d":"60.00"}]
[902,"碳酸锂稳定情绪的中枢机制","中国科学院深圳理工大学(筹)",{"v":60,"d":"60.00"}]
[903,"睡眠调控干预药物成瘾的丘脑室旁核环路机制研究","中国科学院深圳理工大学(筹)",{"v":60,"d":"60.00"}]
[904,"趋化因子MCP1介导的外周血中CD8+ T细胞浸润在阿尔茨海默症中的分子机制","中国科学院深圳理工大学(筹)",{"v":40,"d":"40.00"}]
[905,"基于Shank3突变诱导的自闭症模型研究介导肠动力障碍的神经环路机制","中国科学院深圳理工大学(筹)",{"v":30,"d":"30.00"}]
[906,"肉桂醛介导PI3K/AKT/mTOR自噬轴改善高糖诱导心肌细胞损伤和凋亡的分子机制","中国医学科学院阜外医院深圳医院",{"v":27,"d":"27.00"}]
[907,"DNA甲基转移酶DNMT3A参与FBXO6介导Smad3泛素化途径在急性心肌梗死心肌纤维化中的作用及机制研究","中国医学科学院阜外医院深圳医院",{"v":21,"d":"21.00"}]
[908,"心室辅助泵内流动致血小板激活、黏附及泵内血栓形成的机制研究","中国医学科学院阜外医院深圳医院",{"v":17,"d":"17.00"}]
[909,"vNOTES全子宫+前哨淋巴结切除治疗I期子宫内膜癌的前瞻性临床研究","中国医学科学院肿瘤医院深圳医院",{"v":30,"d":"30.00"}]
[910,"CPS1介导的代谢重编程在卵巢癌耐药中的机制研究","中国医学科学院肿瘤医院深圳医院",{"v":30,"d":"30.00"}]
[911,"自噬基因表达变化与原发性肝细胞癌d-TACE抵抗相关性的研究","中国医学科学院肿瘤医院深圳医院",{"v":20,"d":"20.00"}]
[912,"蚊虫体内微生物全感染组及其相互作用研究","中山大学·深圳",{"v":60,"d":"60.00"}]
[913,"利用小头症模型对大脑皮层神经干细胞分化的表观遗传调控分子机制的研究","中山大学·深圳",{"v":60,"d":"60.00"}]
[914,"双嵌合巨噬细胞外泌体用于肿瘤协同免疫治疗的研究","中山大学·深圳",{"v":60,"d":"60.00"}]
[915,"酶/ROS双响应的可降解大分子药物递送系统用于胰腺癌靶向治疗","中山大学·深圳",{"v":60,"d":"60.00"}]
[916,"水稻硝酸盐吸收和同化的遗传机制研究及氮高效种质的创制","中山大学·深圳",{"v":60,"d":"60.00"}]
[917,"生物粘附纳米粒经鼻腔给药对脑缺血再灌注损伤的保护作用及机制研究","中山大学·深圳",{"v":60,"d":"60.00"}]
[918,"基于细菌特异性代谢底物及单线态氧智能控释的多功能靶向抗菌光敏剂的设计、合成及其生物活性研究","中山大学·深圳",{"v":60,"d":"60.00"}]
[919,"响应型多氮唑配位聚合物与葡萄糖氧化酶纳米复合材料用于癌症联合治疗","中山大学·深圳",{"v":60,"d":"60.00"}]
[920,"自支撑复合薄膜的室温低场磁电耦合性能调控","中山大学·深圳",{"v":60,"d":"60.00"}]
[921,"α-突触核蛋白促进小胶质细胞过度活化导致神经毒性损害的机制研究","中山大学附属第八医院（深圳福田）",{"v":30,"d":"30.00"}]
[922,"SARS-CoV-2疫苗接种后机体免疫优势应答谱学与保护机制研究","中山大学附属第八医院（深圳福田）",{"v":30,"d":"30.00"}]
[923,"马尔尼菲篮状菌通过巨噬细胞ERK/MAPK/IL-10通路上调Treg细胞分化介导免疫逃逸机制的研究","中山大学附属第八医院（深圳福田）",{"v":30,"d":"30.00"}]
[924,"基于二茂铁酪胺沉积反应的tiRNA&amp;tRFs生物传感器平台靶向肝癌耐药及早期诊断","中山大学附属第八医院（深圳福田）",{"v":30,"d":"30.00"}]
[925,"新lncRNA 25174在缺氧通过HIF1A/NCOA4通路抑制女性滋养层细胞铁死亡而引发流产中的作用和调控机制","中山大学附属第八医院（深圳福田）",{"v":30,"d":"30.00"}]
[926,"基于pCASL-fNIRS脑影像技术的虚拟现实治疗技术改善慢性疼痛症状的干预效果探索和中枢机制研究","中山大学附属第八医院（深圳福田）",{"v":25,"d":"25.00"}]
[927,"RNF40/H2BK120ub1/TRAF4轴调控MSC成骨分化在老年性骨质疏松症发病及治疗中的作用研究","中山大学附属第八医院（深圳福田）",{"v":20,"d":"20.00"}]
[928,"探索非酒精性脂肪肝的新型基因治疗策略及其机制","中山大学附属第八医院（深圳福田）",{"v":20,"d":"20.00"}]
[929,"肿瘤细胞与免疫细胞的炎症正反馈环路介导结直肠癌耐药","中山大学附属第八医院（深圳福田）",{"v":20,"d":"20.00"}]
[930,"基于新型可降解的自组装纳米药物用于肿瘤放疗增敏的研究","中山大学附属第八医院（深圳福田）",{"v":20,"d":"20.00"}]
[931,"PS靶向诱导肿瘤铁死亡催化治疗的原位监测研究","中山大学附属第八医院（深圳福田）",{"v":20,"d":"20.00"}]
[932,"神经嵴干细胞来源P2RY1-MSCs治疗下肢缺血疾病的作用机制研究","中山大学附属第八医院（深圳福田）",{"v":19,"d":"19.00"}]
[933,"Apelin-13通过下调LncRNA BDNF-AS激活BDNF/TrkB通路调节缺血 缺氧神经干细胞的增殖分化改善缺血性卒中神经后遗症的机制研究","中山大学附属第八医院（深圳福田）",{"v":9,"d":"9.00"}]
[934,"Nogo-B调控肿瘤微环境中免疫细胞分化在肺癌进展中的作用","中山大学附属第七医院（深圳）",{"v":60,"d":"60.00"}]
[935,"阿尔茨海默病中细胞外囊泡通过递送补体C1q促进神经元β淀粉样蛋白生成的机制研究","中山大学附属第七医院（深圳）",{"v":33,"d":"33.00"}]
[936,"TMEM43-S358L突变通过PPARγ信号通路调控致心律失常性右室心肌病心脏脂肪堆积的分子机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[937,"CD11bintCD11cint单核吞噬细胞通过IRF8调节免疫平衡促AKI肾脏修复的机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[938,"应用单细胞转录组测序技术解析儿童再生障碍性贫血患者的TCR组库特征与动态演化","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[939,"小分子抑制剂JI6的丙烯酰胺衍生物作为FLT3不可逆抑制剂在AML靶向治疗中的作用机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[940,"3D打印仿生脊髓支架联合ADSCs诱导神经再生促进SCI功能恢复及机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[941,"激活脑微血管内皮细胞Wnt/β-catenin上调MEF2C表达从而减轻AD中血脑屏障损伤的机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[942,"靶向星形胶质细胞连接蛋白半通道改善慢性睡眠不足引起的认知障碍的作用及机制","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[943,"LncRNA MIR2052HG介导前列腺癌细胞干性维持并诱导骨髓壁龛迁移的分子机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[944,"LncRNA-LCAL4激活IL-6/STAT3信号通路促进乳腺癌骨转移的机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[945,"PEI-AuNPs-miR-126/SAPNS功能化纳米“芯片”移植调控内源性神经干细胞修复脊髓损伤的作用及机制研究","中山大学附属第七医院（深圳）",{"v":30,"d":"30.00"}]
[946,"靶向活化肝星状细胞LPAR1的CAR修饰巨噬细胞治疗肝纤维化","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[947,"Rab6通过高尔基体膜泡运输调控肝纤维化的机制研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[948,"运用光遗传学工具研究TrkA信号通路调控先天性巨结肠症中肠神经发育的作用与机制","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[949,"GPR158靶向AKT-mTORC1信号通路调控社交趋新行为的机制研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[950,"基于内源性多肽组学技术探究GPR158介导酒精使用障碍发病的分子机制","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[951,"脑梗死通过细胞碎片过载增加脑小血管病发生及Cathepsin B在其中作用的研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[952,"ALKBH5通过m6A甲基化修饰调控UHRF1介导的滤泡T细胞分化在SLE中的作用及机制研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[953,"液态核磁共振研究滑膜肉瘤中致病型突变SS18-SSX蛋白与G4核酸相互作用及其药物苗头化合物的筛选","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[954,"聚β氨基酯载体用于铂类耐药复发性卵巢癌化疗联合免疫治疗的研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[955,"靶向内质网应激应答分子通路诊疗低级别恶性胶质瘤干细胞的研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[956,"LIN28-YAP1信号轴通过增强肿瘤细胞干性促进三阴乳腺癌增殖和转移的机制研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[957,"核酸纳米探针用于活细胞DNA表观遗传学关键酶的动态分析及抑制剂筛选","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[958,"氧化应激自增强激活NO原位释放的多功能纳米递药体系用于多药耐药前列腺癌的治疗研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[959,"基于Dot/Icm IV型分泌系统效应蛋白多态性的嗜肺军团菌毒力机制研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[960,"Nestin通过IRE1α调控内质网应激在间质干细胞衰老中的作用及机制研究","中山大学附属第七医院（深圳）",{"v":20,"d":"20.00"}]
[961,"双肾上腺素样激酶DCLK1诱导雄激素受体活化与“干性维持”促进PCa去势抵抗的机制研究","中山大学附属第七医院（深圳）",{"v":18,"d":"18.00"}]
[962,"Sunitinib作为酪氨酸磷酸酶SHP2突变抑制剂在JMML靶向治疗中的作用机制研究","中山大学附属第七医院（深圳）",{"v":10,"d":"10.00"}]
[963,"血小板生成素受体激动剂的双重靶标筛选及其调控巨核细胞动态发育的分子机制","中山大学深圳研究院",{"v":60,"d":"60.00"}]
[964,"薇甘菊的种群表观基因组学研究：剖析环境因子之间的相互作用","中山大学深圳研究院",{"v":60,"d":"60.00"}]
[965,"多种农药残留同步即时检测技术与便携式装置研究","中山大学深圳研究院",{"v":60,"d":"60.00"}]
[966,"基于自监督学习与时空动态建模的行为识别技术研究","中山大学深圳研究院",{"v":40,"d":"40.00"}]
[967,"甲酸自由基驱动的高级还原技术对污水中新型微污染物的去除机制研究","中山大学深圳研究院",{"v":40,"d":"40.00"}]
[968,"高不确定动态约束下无人驾驶的规划与控制技术研究","中山大学深圳研究院",{"v":40,"d":"40.00"}]

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